Navigation Links
Sinapis Pharma Completes Phase I Trial
Date:7/11/2011

JACKSONVILLE, Fla., July 11, 2011 /PRNewswire/ -- Sinapis Pharma, Inc. is pleased to announce that it has completed its first clinical trial in the development of its lead drug for the treatment of stroke and traumatic brain injury.  The Phase I trial entitled " A Phase 1, Open-Label, Randomized, Two-Period, Two-Treatment, Two-Sequence, Single Dose, Crossover Study to Evaluate the Safety and Pharmacokinetics of Oral and Intravenous Administration of Methamphetamine Hydrochloride in Healthy Volunteers" was conducted at Prism Research in St. Paul, MN.

This was a single-center, open-label, randomized, two-period, two-treatment, two-sequence, single dose, crossover study of the safety and pharmacokinetics of oral and IV administration of methamphetamine HCl in six healthy volunteers.  Subjects were randomized 1:1 to receive a single oral dose of methamphetamine HCl (5 mg Desoxyn® tablet) or a single IV dose of methamphetamine HCl (5 mL of 0.5 mg/mL methamphetamine HCl injection infused over one hour for a total dose of 2.5 mg), and then crossed over to the other treatment (i.e., IV or oral dose, respectively) after a 10 day washout period.  Subjects received a single dose of study drug on Day 1 of each of the two treatment periods.

The trial successfully demonstrated the safety of an IV infusion of Methamphetamine and produced the IV infusion pharmacokinetics needed to initiate Phase IIa clinical studies in stroke patients.

Sinapis plans to initiate its Phase IIa trial in stroke patients before year end.

Dr Donald Picker, Sinapis CEO, said  "We are very pleased  and excited to complete the next step in the development of this drug for stroke and traumatic brain injury patients. We are eager to begin the proof of principle trials in these very important indications where there are currently no effective treatments."

Sinapis Pharma, Inc. (www.sinapispharma.com'/>"/>

SOURCE Sinapis Pharma, Inc
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2

Related biology technology :

1. Laszlo Radvanyi, Ph.D. Joins Genesis Biopharma Scientific and Medical Advisory Board
2. SCOLR Pharma, Inc. Announces Final Closing of Private Placement
3. Inovio Pharmaceuticals DNA Vaccine for Foot-and-Mouth Disease Generates Protective Neutralizing Antibodies in Second Large-Animal Study
4. Dr. Joel Posener Joins PharmaNet as Executive Medical Director, Neuroscience
5. PharmaNet Extends Expiration Time in its Tender Offer and Consent Solicitation
6. Inovio Pharmaceuticals Prostate Cancer DNA Vaccine Demonstrates Strong T Cell Responses in Monkeys; Company on Track for Phase I Clinical Trial
7. Genesis Biopharma Conference Call and Webcast Reminder
8. PharmAthene Selected for Inclusion in the Russell Global Index and Russell 3000 Index
9. PharmAthene Achieves Anthrax Vaccine Program Milestone and Successfully Completes Technology Transfer
10. PharmacoFore, Inc. Announces Appointment of Chief Medical Officer and Vice President of Intellectual Property
11. Oramed Pharmaceuticals Appoints Dr. Michael Berelowitz as Chairman of Scientific Advisory Board
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/2/2014)... CA (PRWEB) October 02, 2014 ... high throughput research solutions for biopharmaceutical development, today ... 23 - 24, 2014 at GlaxoSmithKline (GSK) in ... and discussions of best practices in high throughput ... Summit, R&D leaders gathered together to discuss the ...
(Date:10/2/2014)... At a time when many are feeling their ... a new kind of squeeze aimed at containing lab costs ... Squeeze Riteā„¢ Wash Bottle , catalog no. F11717-0030. Innovative in ... reduces the waste of reagents, solutions and other liquids by ... to squeeze when compared to standard 500ml bottles, its unique ...
(Date:10/2/2014)... SIRO Clinpharm, an award-winning Clinical ... prestigious Annual Conference of the Society for Clinical Data ... , where they were invited to speak at three ... analytics to support fraud detection, ,clinical data management,s role ... working together as virtual and integrated teams,. The award-winning ...
(Date:10/1/2014)... 2014 Weighing applications in pharmaceutical ... final product. However, while the pharmaceutical industry is ... as Good Manufacturing Practices (GMP) usually provide only ... manufacturer to interpret these guidelines and assess process ... METTLER TOLEDO experts have created a new white ...
Breaking Biology Technology:Freeslate European Summit Highlights Best Practices in High Throughput Research and Data Management 2New Wash Bottle Reduces Waste of Reagents, Solutions, and Other Liquids 2SIRO Clinpharm Showcases Biometrics Capabilities at the SCDM 2014 Annual Conference in Las Vegas 2Comply with Weighing-Related Regulations in Pharma Manufacturing 2
... first time, researchers at North Carolina State University ... are physically or chemically different so-called Janus ... an alternating electrical field is applied to liquid ... research, published in the Feb. 8, 2008, edition ...
... Pharmaceuticals,Inc. (Nasdaq: ARNA ) today reported financial results ... 2007., Total revenues in the fourth quarter of ... fourth quarter of 2006. Total revenues in,the full year ... $30.6,million in the full year ended December 31, 2006, ...
... /PRNewswire/ -. Mr. Richard W.,Decker II will be ... Biological Center (ECBC) March 2. He has served ... of Engineering within the,organization since February 2005., ... 1,600 Department,of the Army civilians, soldiers and on-site ...
Cached Biology Technology:'2-faced' particles act like tiny submarines 2Arena Pharmaceuticals Announces Fourth Quarter and Full Year 2007 Financial Results 2Arena Pharmaceuticals Announces Fourth Quarter and Full Year 2007 Financial Results 3Arena Pharmaceuticals Announces Fourth Quarter and Full Year 2007 Financial Results 4Arena Pharmaceuticals Announces Fourth Quarter and Full Year 2007 Financial Results 5Arena Pharmaceuticals Announces Fourth Quarter and Full Year 2007 Financial Results 6Arena Pharmaceuticals Announces Fourth Quarter and Full Year 2007 Financial Results 7Arena Pharmaceuticals Announces Fourth Quarter and Full Year 2007 Financial Results 8Arena Pharmaceuticals Announces Fourth Quarter and Full Year 2007 Financial Results 9Arena Pharmaceuticals Announces Fourth Quarter and Full Year 2007 Financial Results 10Arena Pharmaceuticals Announces Fourth Quarter and Full Year 2007 Financial Results 11Mr. Richard Decker Appointed Technical Director of Edgewood Chemical Biological Center 2
(Date:10/1/2014)... Scientists have discovered a new form of non-genetic inheritance, ... a mother,s previous sexual partner in flies at ... to ancient Greek times, but was discredited in the ... test it out, UNSW Australia scientists Dr Angela Crean, ... size of male flies and studied their offspring., They ...
(Date:9/30/2014)... Millions of tourists visit the Mediterranean each year, ... currently underway on Earth. Almost 1,000 alien species, ... from other seas through human activities. In the ... a multinational team of researchers analyzed data from ... Commission to show how the introduction of alien ...
(Date:9/30/2014)... all have in common? Unlike most eukaryotic multicellular ... diploid, these organisms are all polyploid, meaning they have ... have 3 and 4 sets of chromosomes, respectively, and ... in fact most plant species are polyploid. Polyploidy, or ... but only recently, with the development of molecular tools, ...
Breaking Biology News(10 mins):Semen secrets: How a previous sexual partner can influence another male's offspring 2Biodiversity in the Mediterranean is threatened by alien species 2Gene doubling shapes the world: Instant speciation, biodiversity, and the root of our existence 2Gene doubling shapes the world: Instant speciation, biodiversity, and the root of our existence 3Gene doubling shapes the world: Instant speciation, biodiversity, and the root of our existence 4
... popularity of garlic as a food ingredient and its ... the distinctive pungency associated with its raw, uncooked state. ... a characteristic mixture of burning and prickling sensations and ... a particular compound and its ability to activate specific ...
... nonprofit pharmaceutical company in the U.S., announced today it ... regulatory agencies in the world, the Food and Drug ... of Medicinal Products (EMEA), for paromomycin to treat visceral ... ("black fever"), is a fatal disease transmitted by sand ...
... complaint against British drug maker GlaxoSmithKline (GSK) over its ... proceed following an order late last week by South ... go forward. GSK has sought outright dismissal of the ... week giving the complainants, AIDS Healthcare Foundation (AHF) and ...
Cached Biology News:Activation of thermoreceptors mediates raw garlic's burning pungency 2OneWorld Health drug receives 'Orphan' designation from U.S. and European regulatory agencies 2South African Tribunal Asks For Damages Estimates in GSK AIDS Drug Case 2
Lingo-1 (K-13)...
... well-characterized tissue-specific stem cells that exhibit remarkable ... life-long maintenance of the hematopoietic system. HSC ... bone marrow where hematopoiesis is continuously taking ... cord blood, fetal liver, adult spleen and ...
Human DEP-1/CD148 Fluorescein MAb (Clone 143-41) Protein Family: Granulocyte Markers, Monocyte Markers, Phosphatases & Regulators, Other Dendritic Cell Molecules...
MOUSE ANTI PORCINE SLA 1:FITC Immunogen: Porcine peripheral blood mononuclear cells....
Biology Products: