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Silence Therapeutics Signs Collaboration With Mirna Therapeutics to Evaluate Delivery of Novel microRNA Therapeutics
Date:10/23/2011

LONDON, October 24, 2011 /PRNewswire/ --

Silence Therapeutics plc (AIM: SLN) ("Silence"), a leading RNA interference (RNAi) therapeutics company, today announced that it has entered into an agreement with Mirna Therapeutics Inc. ("Mirna"), a biopharmaceutical company pioneering microRNA-based therapeutics for cancer, to assess the delivery capabilities of Silence's proprietary AtuPLEX™ and DBTC delivery systems for Mirna's novel microRNAs.

Under the terms of the agreement, Mirna will provide Silence with specific miRNA sequences, which Silence will formulate with its AtuPLEX™ and DBTC delivery systems in order to develop multiple candidate drugs.  Mirna will undertake in vitro and in vivo studies of the candidate drugs developed under the agreement and select lead candidates for further evaluation. Financial terms of the deal were not disclosed.

Thomas Christély, Chief Executive Officer of Silence Therapeutics, said: "We are delighted to be collaborating with Mirna. This is our second collaboration exploring the use of Silence's delivery technologies to deliver microRNAs. However, it is Silence's first collaboration involving our new DBTC liver delivery system. Whilst internally we remain focused on the delivery of our siRNA therapies, we continue to look to broaden the potential value of our delivery systems by partnering them with other companies for use in multiple applications. Functional delivery of effective doses into target cells is one of the greatest challenges facing most nucleic acid therapies. With our delivery systems AtuPLEX™, DACC and DBTC, Silence has an increasing range of delivery options to help overcome these challenges."  

Paul Lammers, MD, President and Chief Executive Officer of miRNA Therapeutics, said: "We are very interested to be working with Silence Therapeutics on the delivery of our m
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SOURCE Silence Therapeutics Plc
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