Navigation Links
Silence Therapeutics Receives Comprehensive Protection for RNAi Structural Modification Technology in Single European Patent
Date:10/20/2010

LONDON, Oct. 20 /PRNewswire/ -- Silence Therapeutics plc (AIM: SLN) ("Silence" or the "Company") announces that the European Patent Office (EPO) has granted a new patent that provides broad protection on novel aspects of the RNAi structural modification technology known as the "Zamore Design Rules."  European patent number 1 633 890 titled "Methods and Compositions for Enhancing the Efficacy and Specificity of RNAi" was published today in the European Patent Bulletin.  The European patent covers various breakthrough structural modification methods and compositions which Silence believes are fundamental for the development and commercialization of RNAi therapeutics with enhanced efficacy.

"The granting of this comprehensive patent in Europe is a significant milestone for Silence in our ongoing effort to build one of the world's leading RNAi intellectual property positions.  We have consistently built a strong IP estate around the Zamore technology in the U.S. and have now extended our global coverage to Europe with the granting of this critical patent," stated Philip Haworth, Ph.D., chief executive officer of Silence Therapeutics.  "We have often stated our belief that the 'Zamore Design Rules' represent significant IP to enable the process of bringing effective RNAi therapeutics to market.  With this latest patent grant from the EPO, we are excited to be able to offer potential collaborators or licensing partners access to this strongly protected Zamore technology in both the U.S. and Europe."

The issued patent's method and composition claims include:

  • Methods of enhancing the ability of an antisense strand of an RNAi agent to act as a guide strand
  • RNAi or siRNA agents for enhancing silencing of a target mRNA in a subject
  • Compositions for siRNA duplexes include pre-miRNA and shRNA and vectors to perform the methods described herein

Silence owns excl
'/>"/>

SOURCE Silence Therapeutics plc
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3

Related biology technology :

1. Silence Therapeutics Partner Quark Signs Exclusive Option Agreement With Novartis for Development and Commercialisation of QPI-1002
2. Silence Therapeutics Expands RNAi Structural Modification IP Portfolio With Issuance of New U.S. Patent
3. Silence Therapeutics Issued Novel RNAi Patent Covering High-Value Cancer Target in United States
4. Silence Therapeutics Appoints New Vice President of Research
5. Silence Therapeutics to Present at 12th Annual BIO CEO & Investor Conference
6. National Ovarian Cancer Coalition and PureOlogy to Host First Annual NOCC and PureOlogys Walk to Break the Silence on Ovarian Cancer
7. Precision Therapeutics President and CEO Sean McDonald Recognized as Pittsburgh Technology Council Tech 50 CEO of the Year
8. Fate Therapeutics Announces Collaboration With BD to Develop and Commercialize Induced Pluripotent Stem Cell Technology
9. Northwest Biotherapeutics to Present at Inaugural Cancer Immunotherapy Conference
10. Orexigen® Therapeutics Announces Upcoming Data Presentations at the 28th Annual Scientific Meeting of The Obesity Society
11. Cell Therapeutics, Inc. (CTI) to Present at 9th Annual BIO Investor Forum
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/10/2014)... to the International Atomic Energy Agency (IAEA) the ... acquiring sufficient quantities of plutonium or highly enriched ... device. The IAEA also notes that most cases ... which can be challenging to detect with most ... appearing this week in the Journal of ...
(Date:7/10/2014)... published today in the journal PNAS (Proceedings of ... time of day and sleep deprivation have a significant ... when looking at the best time of day to ... and for administering medicines effectively. , Researchers from the ... London, investigated the links between sleep deprivation, body clock ...
(Date:7/10/2014)... The lithium-ion batteries that power our laptops and ... on a single charge with the help of a ... material to replace the graphite traditionally used in one ... 10 times the energy storage capacity of graphite. A ... electrode was published today in Nature Communications . ...
(Date:7/10/2014)... A recent study by researchers at the University ... the physical mechanisms governing the interplay of spin ... fundamental limits of ultrafast spintronic devices for data ... a charge as well as spin-angular momentum. In ... so there is no spin current," explained David ...
Breaking Biology Technology:Sensitive detection method may help impede illicit nuclear trafficking 2Time of day crucial to accurately test for diseases, new research finds 2Silicon sponge improves lithium-ion battery performance 2Silicon sponge improves lithium-ion battery performance 3University of Illinois study advances limits for ultrafast nano-devices 2
... , , ... luminescence of lanthanide ions has long been a challenge for the spectroscopist. Methods to counter ... Protective ligands to reduce vibrational quenching effects by XH ... Deuterated solvents (also to reduce quenching effects of XH). , ...
... , , , The optical properties of quantum dots (QDs) have potential applications, ... memory devices, and ... herein to possess a nonlinear change ... correlated to size and composition, as monitored by the versatile, ...
... , ... The chemistry, spectroscopy, and reactivity of singlet oxygen, 1 O 2 ... mechanisms of photo-oxygenation. 1 Recently, research has been directed towards understanding ... photodynamic destruction of cells in the presence of a dye, oxygen, and ...
Cached Biology Technology:Time gated separation of lanthanide luminescence 2Photoluminescence Spectroscopy of Quantum Dots, monitored by the Spex FluoroMax 2Photoluminescence Spectroscopy of Quantum Dots, monitored by the Spex FluoroMax 3Photoluminescence Spectroscopy of Quantum Dots, monitored by the Spex FluoroMax 4Singlet Oxygen measurement 2
(Date:7/11/2014)... Sweden, have explored two different ways that allow ... to the formation of oxygen molecules in photosynthesis. ... scientific journal Nature Communications . , "The ... catalysts for water oxidation, which are key components ... storage of solar energy in fuels like hydrogen, ...
(Date:7/11/2014)... demonstrated that transplantation of mesenchymal stem cells can stimulate ... models of Alzheimer,s disease (AD) and improve tissue and ... studies are reported on the therapeutic effect of adipose-derived ... on the effect on oxidative injury and neurogenesis in ... her team, School of Life Sciences, Tsinghua University, China ...
(Date:7/11/2014)... 1 can inhibit voltage-gated calcium channel, decrease ... However, some scholars demonstrated that cannabinoid receptor ... and increase neurotransmitter release. Dr. Yi Zhang ... Tongji Medical College, Huazhong University of Science ... and calcium imaging in cultured trigeminal ganglion ...
Breaking Biology News(10 mins):Molecular snapshots of oxygen formation in photosynthesis 2
... Claims that tropical forests are declining cannot be backed up ... of Leeds. This major challenge to conventional thinking is ... Proceedings of the US National Academy of Sciences by Dr ... world,s leading experts on tropical deforestation. "Every few years ...
... Biotech Inc. (TSX: ONC, NASDAQ: ONCY) (Oncolytics) reported ... Richard Vile of the Mayo Clinic College of ... its work testing the antitumor efficacy and safety ... vivo. The paper, entitled Cyclophosphamide Facilitates Antitumor ...
... -- The National Academy of Sciences (NAS) and Institute ... a book designed to give the public a comprehensive ... evolution and its importance in the science classroom. ... abundance of observations and experiments over the past 150 ...
Cached Biology News:No convincing evidence for decline in tropical forests 2No convincing evidence for decline in tropical forests 3Scientific evidence supporting evolution continues to grow 2Scientific evidence supporting evolution continues to grow 3
... Formula variant: With the macro- ... Murashige and Skoog (1962) and ... Gamborg, et al. (1968). Preparation ... 4.4 grams of powder per ...
... provides a fast and simple procedure for concentrating ... exchange, and for removing different types of salts ... spin-column chromatography using Norgens patented protein resin as ... , NaCl, KCl, CaCl 2 , LiCl, and ...
... Surveyor software provides local instrument control ... HPLC Systems. The software operates on ... Windows Pocket PC 2002 O/S and ... directly to their Surveyor quaternary gradient ...
... CHEMICONs Blood Vessel Staining Kit is ... detection of vascular endothelial cells, containing both ... and is applicable to a variety of ... all-in-one method for the staining of frozen ...
Biology Products: