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Silence Therapeutics Provides Corporate and Development Update
Date:11/8/2011

LONDON, November 8, 2011 /PRNewswire/ --

Silence Therapeutics plc (AIM: SLN) ("Silence" or the "Company"), a leading RNA interference (RNAi) therapeutics company, today provides an update on recent business and clinical developments.

Expansion of business development team

Silence today announces the appointment of Dr Georg Buchner as VP Business Development. Georg will work with Tony Sedgwick who was appointed as Silence's Chief Business Officer in September as part of the Company's strategy to continue to broaden its collaborations with global pharmaceutical and biotechnology companies. Georg was formerly VP of Corporate & Business Development at Novacta Biosystems Ltd. Prior to joining Novacta, Georg was Business Development Director at Haptogen Ltd and was instrumental in the sale of the business to Wyeth (now part of Pfizer) in 2007. Georg gained a PhD in Molecular Genetics from King's College London and an MBA from The University of Cambridge's Judge Institute of Management.

Atu027 trial update

Results from the ongoing Phase I trial of Atu027, Silence's lead siRNA development programme for the treatment of advanced solid cancer, now confirm that 10 out of 27 (37%) patients treated to date have shown stable disease after the treatment phase of the trial. Dosing of the first patient in cohort 10 of the 11 cohort trial has now commenced and the trial is on track to complete recruitment in early 2012 with results reported by mid-2012.  Atu027 incorporates AtuPLEX™, Silence's proprietary delivery technology that transports RNAi molecules to the target site with high specificity.

Atu134 development update

Following further encouraging data generate
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SOURCE Silence Therapeutics Plc
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