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Silence Therapeutics' Lead RNA Interference Therapeutic Prevents Spread of Cancer to Lungs
Date:11/10/2010

LONDON, Nov. 10, 2010 /PRNewswire/ -- Silence Therapeutics plc (AIM: SLN) ("Silence" or the "Company") announces positive research findings demonstrating the ability of the Company's lead RNA interference (RNAi) drug candidate, Atu027, to prevent the formation of pulmonary metastasis in various animal models of cancer metastasis.  Researchers showed that Atu027 inhibited multiple key biological processes that enable and contribute to the dissemination and formation of pulmonary metastases in a murine breast cancer metastasis model.  It is important to note that breast cancer cells prefer to metastasize through the bloodstream to the lung.  The findings were published in the latest edition of the scientific journal Clinical Cancer Research in a peer-reviewed paper entitled; "Atu027 Prevents Pulmonary Metastasis in Experimental and Spontaneous Mouse Metastasis Models."

Atu027 is a proven inhibitor of the expression of PKN3, a molecule that is believed to play an important role in the progression of cancer and metastasis formation in particular.  In the study, researchers administered Atu027 to multiple mouse models of breast cancer to evaluate the drug's ability to prevent the spread of the cancer to the lungs.  Study data demonstrated that Atu027 has a clear inhibitory effect on the formation of pulmonary metastasis.  With metastasis directly linked to high rates of mortality in cancer patients, the prevention of metastasis dissemination and formation is a critical goal of cancer treatment.

"While the demonstrated inhibition of pulmonary metastasis formation was a positive and important outcome of this study, equally important is what we learned regarding the manner in which Atu027 is able to achieve this effect.  These findings showed that in addition to our previously published research demonstrating its ability to inhibit metastasis through the lymphatic system, Atu027 also appears to interrupt the metas
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SOURCE Silence Therapeutics plc
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