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Silence Therapeutics Expands RNAi Structural Modification IP Portfolio With Issuance of New U.S. Patent
Date:7/7/2010

LONDON, July 7 /PRNewswire/ -- Silence Therapeutics plc (AIM: SLN) ("Silence" or the "Company") announces the issuance of United States patent 7,750,144, titled Methods and Compositions for Enhancing Efficacy and Specificity of RNA Silencing, by the United States Patent and Trademark Office (USPTO).  The issued patent generally claims methods of producing double stranded (RNAi) agents having decreased off-target silencing activity through certain structural modifications.  The ability to minimize the off-target effects of RNAi therapeutics is critical for controlling unwanted cellular activity and/or potential safety concerns.  The issued claims not only cover minimizing off-target gene expression silencing using short interfering RNA (siRNA) but also include specific claims directed to micro RNA (miRNA).  

This latest issued patent is based on the seminal research of Phillip D. Zamore, Ph.D., Howard Hughes Medical Institute Investigator, the Gretchen Stone Cook Chair of Biomedical Sciences, and Professor of Biochemistry & Molecular Pharmacology at University of Massachusetts Medical School.  Silence owns exclusive licenses in the human healthcare fields to three Zamore patent families from the University of Massachusetts Medical School, where Zamore is the co-director of the RNA Therapeutics Institute.  These patent families disclose various efficacy-enhancing methods and structural elements for RNAi therapeutics, informally known as the Zamore "Design Rules" and based on Dr. Zamore's work at UMass Medical School.  This is the third patent to issue among the Zamore design rule patents licensed by UMass Medical School to Silence.  The Comp
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SOURCE Silence Therapeutics plc
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