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Silence Therapeutics Announces Positive Outcome From Oral Hearing at the European Patent Office
Date:12/7/2011

cutive Officer of Silence, said: "We are very pleased with the outcome of this oral opposition hearing, which has upheld the key part of our claims in this granted patent. In addition to this granted patent on PKN3, our Atu027 clinical program is also protected by further granted patents and patent applications for the formulation with Silence's AtuPLEX™ delivery technology, the sequence of the siRNA molecules and the AtuRNAi chemistry used in the sequence. Our Atu027 trial continues as planned with two patients now recruited for cohort 10 out of 11 dose levels, and we are still on track to complete recruitment in early 2012 with results reported by mid-2012."

Notes for editors                  

About Silence Therapeutics plc (http://www.silence-therapeutics.com)

Silence Therapeutics plc (AIM: SLN) is a leading biotechnology company dedicated to the discovery, development and delivery of targeted, systemic RNA interference (RNAi) therapeutics for the treatment of serious diseases. Silence offers one of the most comprehensive short interfering RNA (siRNA) therapeutic platforms available today based on a strong intellectual property portfolio and large clinical safety database. Silence's clinical siRNA product pipeline is one of the broadest in the industry. The Company possesses multiple proprietary siRNA delivery technology platforms including AtuPLEX™, DACC and DBTC. AtuPLEX enables the broad functional delivery of siRNA molecules to targeted diseased tissues and cells, while increasing their bioavailability and intracellular uptake. The DACC delivery system allows functional delivery of siRNA molecules selectively to the lung endothelium with a long duration of target mRNA and protein knock-down. The DBTC delivery system enables functional delivery o
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