Navigation Links
Silence Therapeutics Announces Positive Outcome From Oral Hearing at the European Patent Office
Date:12/7/2011

LONDON, December 7, 2011 /PRNewswire/ --

Silence Therapeutics plc (AIM: SLN) ("Silence" or the "Company"), a leading RNA interference (RNAi) therapeutics company, announces a positive outcome from the oral hearing on 6 December 2011 at the European Patent Office (EPO) over opposition to Silence's granted European Patent EP 1 536 827 "Further use of protein kinase N beta".

The granted patent refers to the gene target PKN3, protein kinase N beta, targeted by Silence's lead program Atu027, which is currently in a Phase I clinical study. The Opposition division of the EPO decided to uphold the patent in amended form.

Claim one of the patent relates to the use of protein kinase N beta as a downstream target of the PI3 kinase pathway. Claim two relates to the use of protein kinase N beta as a downstream drug target of the PI3 kinase pathway in a screening process. Both of these claims are maintained as granted, and also the use claims where manufacture of a diagnostic agent is based on use of protein kinase N beta as such (or use of antibodies, spiegelmers, aptamers, ribozymes, antisense molecules and siRNA molecules directed against protein kinase N beta and the nucleic acid molecule coding for these, respectively).

In connection with the use claims where protein kinase N beta as such (or antibodies, spiegelmers, aptamers, ribozymes, antisense molecules and siRNA molecules directed against protein kinase N beta and the nucleic acid molecule coding therefore, respectively) are used for the manufacture of a medicament, the diseases for which such medicament is to be used are now restricted to metastatic cancers. This is the focus of Silence's currently ongoing Atu027 Phase I study with late-stage cancer patients.

Commenting on today's announcement, Thomas Christély, Chief Exe
'/>"/>

SOURCE Silence Therapeutics Plc
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related biology technology :

1. Silence Therapeutics Provides Corporate and Development Update
2. Silence Therapeutics Signs Collaboration With Mirna Therapeutics to Evaluate Delivery of Novel microRNA Therapeutics
3. Silence Therapeutics Issued Japanese Patent Covering its Core RNA Interference (RNAi) Technology
4. Silence Therapeutics Lead RNA Interference Therapeutic Prevents Spread of Cancer to Lungs
5. Silence Therapeutics Receives Comprehensive Protection for RNAi Structural Modification Technology in Single European Patent
6. Silence Therapeutics Partner Quark Signs Exclusive Option Agreement With Novartis for Development and Commercialisation of QPI-1002
7. Silence Therapeutics Expands RNAi Structural Modification IP Portfolio With Issuance of New U.S. Patent
8. Silence Therapeutics Issued Novel RNAi Patent Covering High-Value Cancer Target in United States
9. Silence Therapeutics Appoints New Vice President of Research
10. Silence Therapeutics to Present at 12th Annual BIO CEO & Investor Conference
11. National Ovarian Cancer Coalition and PureOlogy to Host First Annual NOCC and PureOlogys Walk to Break the Silence on Ovarian Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/18/2014)... unprecedented efficiency and data storage may someday ... electric polarizations to read and write digital ... data-driven technology. But ferroelectrics must first overcome ... curious habit of "forgetting" stored data. ... of Energy,s Brookhaven National Laboratory have discovered ...
(Date:8/18/2014)... 2014 According to a ... "Life Science Reagents Market(Products- PCR Reagent Kits, Cell ... Diagnostic Reagents and Others; End Users- Commercial and ... and Forensic Laboratories)- Global Industry Analysis, Size, Share, ... global life science reagents market was valued at ...
(Date:8/18/2014)... , Aug. 18, 2014 TNI BioTech, Inc. ... pioneering the manufacturing and marketing of innovative therapies for ... Company is providing a second notice of TNI BioTech,s ... making the announcement, Noreen Griffin , founder and ... advance for your participation in the Annual Meeting. On ...
(Date:8/18/2014)... 2014 China is increasingly being ... clinical research industry. Clinicaltrial.gov statistics highlight the popularity ... aging population; a high increase in infectious diseases; ... populated pool of patients and a track record ... points, China also presents challenges for the clinical ...
Breaking Biology Technology:Promising ferroelectric materials suffer from unexpected electric polarizations 2Promising ferroelectric materials suffer from unexpected electric polarizations 3Promising ferroelectric materials suffer from unexpected electric polarizations 4Global Life Science Reagents Market Expected to Reach USD 25.7 Billion in 2019: Transparency Market Research 2Global Life Science Reagents Market Expected to Reach USD 25.7 Billion in 2019: Transparency Market Research 3Global Life Science Reagents Market Expected to Reach USD 25.7 Billion in 2019: Transparency Market Research 4Global Life Science Reagents Market Expected to Reach USD 25.7 Billion in 2019: Transparency Market Research 5TNI BioTech Inc., provides 2nd Notice of Annual Meeting September 4, 2014 2TNI BioTech Inc., provides 2nd Notice of Annual Meeting September 4, 2014 3TNI BioTech Inc., provides 2nd Notice of Annual Meeting September 4, 2014 4China – Land of Opportunities & Challenges for the Clinical Research Industry, New Webinar Hosted by Xtalks 2
... the Clinical and Economic Value of Pharmaceuticals in ... ExL Pharma today announced the start of the ... Marketing for the Pharmaceutical Industry at the Loews ... markets marketers with strategic insights needed to prepare ...
... QC, Feb. 9 /PRNewswire-FirstCall/ - LAB Research Inc. ("LRI", ... global non-clinical contract research organization, today announced the nomination ... Board of Directors in replacement of Mr. Karsten Skydsgaard ... the Board to focus on his other professional obligations. ...
... In a paper,published today, scientists at deCODE ... four continents present a novel insight into the ... search in some,10,000 Icelanders, the deCODE team discovered ... human genome (SNPs) that increase levels of,eosinophils in ...
Cached Biology Technology:ExL Pharma Presents The Pharmaceutical Managed Markets Insight & Marketing for the Pharmaceutical Industry Conference 2ExL Pharma Presents The Pharmaceutical Managed Markets Insight & Marketing for the Pharmaceutical Industry Conference 3LAB Research announces changes to its Board of Directors 2Multinational deCODE Study Identifies New Link Between Inflammation and Heart Attack 2Multinational deCODE Study Identifies New Link Between Inflammation and Heart Attack 3Multinational deCODE Study Identifies New Link Between Inflammation and Heart Attack 4
(Date:8/19/2014)... 19, 2014 To improve students, chances of ... the University of Houston (UH) implemented a comprehensive ... at risk for failure. , Through a ... (THECB), the Department of Biology and Biochemistry embarked ... taking "General Biology" for non-majors and "Introductory Biology" ...
(Date:8/19/2014)... Research and Network-Level Science, , Imagine if we had ... ecosystems was responding to global changes in real time. ... coupled multiple decades of information about ecological responses to ... dozens of different ecosystem types. , In fact, ... (LTER) Network, which will soon celebrate its 35th anniversary. ...
(Date:8/19/2014)... at retail seafood counters in 10 different states ... consumers to unexpectedly high levels of mercury, a ... a fish of the same species, but from ... offense, according to new research by University of ... seafood is essential to allow consumers to choose ...
Breaking Biology News(10 mins):University of Houson program earns kudos for improving grades, retaining students 2University of Houson program earns kudos for improving grades, retaining students 3This week from AGU: Long-term ecological research, predicting cholera outbreaks 2Seafood substitutions can expose consumers to unexpectedly high mercury 2Seafood substitutions can expose consumers to unexpectedly high mercury 3
... international study fails to support the common belief that ... a key factor in rising rates of obesity. ... compared African American women in metropolitan Chicago with women ... 184 pounds and the Nigerian women weighed 127 pounds. ...
... 6, 2009) − Obstructive sleep apnea decreases blood flow ... and eventually harms the brain,s ability to modulate these ... new study published by The American Physiological Society. The ... are more likely to suffer strokes and to die ...
... The study of ancient microbes may not seem consequential, ... has implications for the state of modern human health. ... says results of this research raise questions about the ... National Institutes of Health initiative is looking at helpful ...
Cached Biology News:Physical activity may not be key to obesity epidemic 2Study helps explain connection between sleep apnea, stroke and death 2Study helps explain connection between sleep apnea, stroke and death 3Understanding extinct microbes may influence the state of modern human health 2Understanding extinct microbes may influence the state of modern human health 3
... spotting and preparation for MS analysis. ... can be accurately and continuously spotted onto ... solutions can be added automatically. This allows ... MALDI-TOF-MS measurements. By using it in conjunction ...
A camera based compact unit for high speed scanning of 2D barcoded tubes in a cluster rack. This reader has been designed to read both 96 and 48 tube rack configurations and be compatible with common...
A compact, high-speed single tube reader unit designed for benchtop 2D barcode reading. The unit can be used with all of ABgene's 2D barcoded tubes, including the 2ml CryoCode tube....
... Enzymatic method stops PCR carry-over ... ,Designed to degrade PCR products from ... nucleic acid templates, which improves amplification ... core reagents and GeneAmp instrument systems ...
Biology Products: