Navigation Links
Significant Reductions in Mortality and Cardiovascular Events Shown Using Blood Pressure-Lowering Treatment in Those Aged 80 and Over
Date:3/31/2008

Lowering the blood pressure of elderly patients could cut their total mortality by a fifth and their rate of cardiovascular events by a third, according to a new study presented today at the American College of Cardiology in Chicago and published simultaneously in the New England Journal of Medicine.

LONDON, March 31 /PRNewswire/ -- The 3,845 patient Hypertension in the Very Elderly Trial (HYVET), which is co-ordinated by scientists from Imperial College London, is the largest ever clinical trial to look at the effects of lowering blood pressure solely in those aged 80 and over. Patients were given either a placebo or the diuretic indapamide slow release (SR) 1.5mg, with the addition of the ACE inhibitor perindopril in tablet form once a day.

The research shows that the benefits of treatment include a 21% (p=0.02) reduction in total mortality rate, a 39% (p=0.05) reduction in stroke mortality rate, a 64% (p<0.001) reduction in fatal and non-fatal heart failures and a 34% (p<0.001) reduction in cardiovascular events. The benefits were apparent within the first year of follow-up.

The reduction in overall mortality was a novel and unexpected result. Earlier trials had demonstrated that reducing blood pressure in the under-80s reduces stroke and cardiovascular events. However, previous smaller and inconclusive studies also suggested that whilst lowering blood pressure in those aged 80 or over reduced the number of strokes, it did not reduce, and even possibly increased, total mortality.

In July 2007 the trial was stopped early on the recommendation of an independent data monitoring committee after they observed significant reductions in overall mortality and stroke in those receiving treatment. The final results of the trial showed a significant reduction in stroke mortality rate, but the reduction in all strokes of 30% did not quite reach statistical significance (p=0.06). In those aged 80 and over, up to half of strokes are fatal and
'/>"/>

SOURCE Imperial College London
Copyright©2008 PR Newswire.
All rights reserved

0

GOOD

Page: 1 2 3 4

Related biology technology :

1. Micromet to Present at the Susquehanna Financial Groups SIGnificant Investment Options Conference on March 4, 2008
2. Kosan Biosciences to Present at the Susquehanna Second Annual SIGnificant Options in Healthcare Conference
3. Exelixis Announces March 4 Webcast of Presentation at the Susquehanna SIGnificant Options in Healthcare Conference
4. InterMune to Present at the SIGnificant Options in Healthcare Conference
5. ViroPharma to Present at the Susquehanna Financial Group Second Annual Significant Options in Healthcare Conference
6. Anadys Pharmaceuticals to Present at the Susquehanna SIGnificant Options in Healthcare Conference
7. Pharmasset to Present at Susquehannas Second Annual SIGnificant Investment Options in Healthcare Conference on Wednesday, March 5th
8. TorreyPines Therapeutics to Present at Susquehanna Financial Groups Second Annual SIGnificant Options in Healthcare Conference
9. AMDL Receives a Significant Updated Appraisal of Its JJB China Production Facilities
10. Significant Progress Made in Nations Preparedness to Respond to Public Health Emergencies; But Gaps in Critical Areas Threaten Overall Readiness
11. Taxotere(R)-Based Chemotherapy Significantly Improved Overall Survival Compared With Standard Anthracycline-Based Chemotherapy in Early Stage Breast Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/15/2008)...hnology for Groundbreaking Nut... MILFORD, Mass., Oct. 15 /-...located at the North,Carolina Research Campus in K...announced today that Waters(R) has been selected a...cience solutions, including mass,spectrometers, li...
(Date:10/15/2008)... Biotek Corp., an innovative,Canadian biotechnolog...,tools for nucleic acids and protein purification,...e isolation of nucleic acids from,environmental sa...A/DNA,Purification Kit. These kits are ideal for e...high quality, inhibitor-free DNA and/or RNA that c...
(Date:10/15/2008)...onal Children,s Program, OJAI, Calif., Oct. 15 /P...Officer of Tishcon Corp and visionary philanthropi...h of low income children in,America. In January 20...,s,President, Vipin Patel, and Vice President, Aru...America. Their donation of thousands of bottles,of...
(Date:10/15/2008)...arkets close at 2:00 p.m. PT ...RNewswire-FirstCall/ -- Masimo Corporation,(Nasdaq...easure-Through-Motion- and-Low-Perfusion pulse oxi...er financial results for the period ended,Septembe...ber 27, 2008., A conference call to review the re...
Breaking Biology Technology:David H. Murdock Research Institute Taps Waters for Laboratory Technology 2David H. Murdock Research Institute Taps Waters for Laboratory Technology 3High-quality DNA/RNA from Microorganisms in Environmental Samples 2Tishcon Corp Reaches Donation Milestone Exceeds 1 Million Bottles of Multi-Vitamins for Nourish America 2Tishcon Corp Reaches Donation Milestone Exceeds 1 Million Bottles of Multi-Vitamins for Nourish America 3Masimo to Report Third Quarter 2008 Financial Results on October 27, 2008 2
... Wisconsin Workforce Resource is inviting represe...to participate in its 2006 Synergy Conference titl...rence is scheduled to take place on Sept. 20 from ...at the University of Wisconsin-Stout Memorial S...t yet accepted their invitations to the conference...
...trepreneurs Nathan Lustig and John Tucker were sti... oft-criticized textbook exchange at the Universi...Matt Stamerjohn thought that students were being r...books back to the bookstore for a quarter of their...out the middleman. , ,So he built a website to co...
...e has announced that it has met a NASDAQ Stock M... to today,s market opening, but has asked for an e... , ,The medical imaging and software developer was...ual and first quarter 2006 reports, or face delist...deadline, but was still awaiting word from the sto...
... by a young researcher to leave the University of...ial consequences of the same-sex union debate in W... physics professor and nanotechnology researcher, ...ison in 2000. At the end of the year, he will take...rsity of Pennsylvania , where he says he will be t...
Other Biology Technology:Conference to address small town development 2Website targets college students nationwide 2Website targets college students nationwide 3Website targets college students nationwide 4Merge files financial reports by market opening 2Departure of nanotech researcher stings UW 2Departure of nanotech researcher stings UW 3
(Date:10/15/2008)...5 October 2008 Fifty-nine leading life scientists...nised by the European Molecular Biology Organizati... Fifty-one of the researchers, distinguished as EM...ries, while eight equally respected scientists com...ate Members, bringing the current membership total...
(Date:10/14/2008)...that is effective at killing broadleaf weeds in co...inois and other Midwestern states, may finally hav...y of Illinois have developed a new grape called Im...r herbicide 2, 4-D. , "In 1946, 2,4-Dichlorophen...r herbicide," said Robert Skirvin, plant biologist...
(Date:10/14/2008)...release is available in Spanish . , An interdi...iralt at the Institute for Research in Biomedicine...titut Catal d,Investigaci Qumica" (ICIQ, Tarragona...o maintain protein p53 stable even when it present... cancer. Giralt, head of the Chemistry and Molecul...
(Date:10/14/2008)...on is the leading cause of infant deaths worldwide...term infants. Current diagnostic tests can be slow...fied potential biomarkers in the blood that can ra...e of microbe. , The circulatory system is a maj...ngsmore and colleagues analyzed plasma samples fro...
Breaking Biology News(10 mins):EMBO honors 59 leading life scientists 2Herbicide-resistant grape could revitalize Midwest wine industry 2Herbicide-resistant grape could revitalize Midwest wine industry 3Design of a compound that stabilizes the main natural suppressor of tumors 2Monkey Gene That Blocks AIDS Viruses Evolved More Than Once 13113 1Monkey Gene That Blocks AIDS Viruses Evolved More Than Once 13113 2Alfacell to Host Fiscal Second Quarter 2008 Financial Results Conference Call and Webcast 3630 1Alfacell to Host Fiscal Second Quarter 2008 Financial Results Conference Call and Webcast 3630 2Zounds 21 Sarasota and Port Richey Hear New Retail Concept Coming 13109 1Zounds 21 Sarasota and Port Richey Hear New Retail Concept Coming 13109 2Zounds 21 Sarasota and Port Richey Hear New Retail Concept Coming 13109 3Jiffy Lube 28R 29 Continues Drive Against Heart Disease with Maintenance Partners for Life Campaign 13104 1Jiffy Lube 28R 29 Continues Drive Against Heart Disease with Maintenance Partners for Life Campaign 13104 2Jiffy Lube 28R 29 Continues Drive Against Heart Disease with Maintenance Partners for Life Campaign 13104 3Jiffy Lube 28R 29 Continues Drive Against Heart Disease with Maintenance Partners for Life Campaign 13104 4
...g robin-sized bird restricted to a few tiny remnan...lombia, in the Central Cordillera of the Andes. I...ded discovery until 1999, and has been identified ...conservation species (see www.zeroextinction.org ...r "little herdsman of Antioquia" by the locals for...
...of Medicine and their colleagues have found that m...dition to their own can acquire new color vision, ...o new sensory information than anticipated. , Thi...ts that when the first ancestral primate inherited...years ago, it probably experienced immediate color...
... sound processing centers in the brains of macaque...mals watch a video. , This study confirms a number...king, in which hearing, taste, touch, sight, and s...rain and only later integrated. The new research, ...stitute for Biological Cybernetics in Tübingen, Ge...
...S) tends to go into remission while women are preg...ng neurodegenerative disease, according to Univers...regnancy-related hormone is responsible for rebuil...In a paper to be published in the February 21 issu...chers from the U of C,s Faculty of Medicine report...
Other Biology News:Recently discovered species gain protection 2Making mice with enhanced color vision 2Making mice with enhanced color vision 3Do you hear what i see? 2Pregnancy hormone key to repairing nerve cell damage 2Pregnancy hormone key to repairing nerve cell damage 3
...ples may be carried out using this high pressure s...System control and data processing is provided by ...legant, powerful and very easy to use software ope... supplied detector is the ground breaking WaveQues...
Narrow-mouth has heavy-duty rim. Approximate graduations are in durable white enamel. Extra large marking space. capacity 125 mL Special grade: student grade
Rabbit polyclonal to MSY2/YBOX2 ( Abpromise for all tested applications). Antigen: Synthetic peptide derived from a region between amino acids 178-227 of human YBX2. (Note: the exact amino acid
Standard Fluka For microscopy (Bact., Hist.)
Biology Products: