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SignalRX Pharmaceuticals Issued U.S. Patent Covering Novel Kinase Inhibitors For Treating Cancer and Other Diseases
Date:11/12/2013

off treatments or to develop resistance or re-establish itself via cancer stem cells," said Donald L. Durden, MD, PhD, SignalRx President and Chief Executive Officer.  "We are among a select group of cancer researchers who are actively developing anticancer drugs with dual inhibitory properties including PI3K/MEK, PI3K/BRAF, PI3K/HDAC, PI3K/PARP, and PI3K/BET bromodomain setting the stage for the most efficacious smart combination anticancer treatments based on evolving cancer biology and personalized oncology paradigms.  In addition, these dual inhibitory drugs solve the problem of early stage clinical trial evaluation of multiple combinations by consolidating at least two of the combination partners into one drug.  Moreover, one molecule hitting two targets in the same cell is the only way to ensure that desired simultaneous blockage of both signaling pathways is achieved in vivo because two separate drugs will always suffer from differing cell penetration, metabolism, pharmacokinetics, etc., which promotes  tumor cell resistance  by diminishing the time and likelihood that useful dual blockage is achieved."

Additional information about these compounds was recently published in the Journal of Medicinal Chemistry (February 14th 2013 issue, volume 56, pages 1922-1939).

About SignalRx Pharmaceuticals  Inc.

SignalRx is a privately held corporation developing small molecule inhibitors of key signaling pathways used by cancer and cancer stem cells to evade treatments.  Such key signaling pathways  include major cell survival mechanisms, epigenetic regulation processes, and  DNA repair actions  encompassing critical targets such as PI3K, MEK, BRAF, Wnt, HDAC,  DNMT, BET bromodomains, and PARP.  SignalRx is leveraging its expertise in PI3K pathway inhibition to be the leader in developing single molecule therapeutics that selectively  inhibi
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SOURCE SignalRx Pharmaceuticals Inc.
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