Navigation Links
SignalRX Pharmaceuticals Issued U.S. Patent Covering Novel Kinase Inhibitors For Treating Cancer and Other Diseases
Date:11/12/2013

SAN DIEGO, Nov. 12, 2013 /PRNewswire-iReach/ -- SignalRX Pharmaceuticals Inc., focused on developing more effective oncology drugs through molecular design imparting multiple target inhibition, today announced the issuance of U.S. Patent No. 8,557,807 entitled "Thienopyranones as kinase inhibitors" by the U.S. Patent and Trademark Office claiming composition of matter for a broad generic molecular scaffold (TP) of compounds that possess novel kinase inhibition profiles aimed at imparting maximum anticancer efficacy.  This U.S. patent grants coverage of the TP scaffold compounds into the year 2029 and is complemented by additional U.S. applications as well as by corresponding patent applications pending in other major markets throughout the world. 

The compounds covered in the patent inhibit PI3 kinase and several other key cancer target kinases such as mTORC1, mTORC2, DNA-PK, PLK1 and PIM1.  Further mechanisms of action include induction of oxidative stress and demonstrated anti-cancer stem cell activity.   Furthermore, certain of these compounds can be molecularly manipulated to maintain their PI3 kinase inhibitory activity while simultaneously also inhibiting certain other key cancer targets providing dual inhibition from a single molecule, in line with the CRIMP (Control Resulting from Inhibition of Multiple Pathways) platform which is focused on the development of more effective cancer treatments.  Additionally, other diseases besides cancer such as, age-related macular degeneration and autoimmune diseases along with various inflammatory diseases all potentially can be treated by the kinase inhibition properties of these compounds.

"This patent is a key member of our growing intellectual property portfolio as it provides protection for the cutting edge efforts to deliberately design molecules having multiple mechanisms of action to overcome the devastating ability of cancer cells to shrug
'/>"/>

SOURCE SignalRx Pharmaceuticals Inc.
Copyright©2012 PR Newswire.
All rights reserved

Page: 1 2 3

Related biology technology :

1. Keryx Biopharmaceuticals, Inc. Announces Upcoming Poster Presentations of Zerenex™ (Ferric Citrate) at the Upcoming American Society of Nephrology Kidney Week 2011 Annual Meeting
2. Convergence Pharmaceuticals Initiates Phase I Multiple Ascending Dose Study for CNV2197944
3. TetraLogic Pharmaceuticals Announces Initiation of a Phase 1/2 Clinical Trial of TL32711 in Patients with Acute Myelogenous Leukemia (AML)
4. Questcor Pharmaceuticals to Present at the Oppenheimer Healthcare Conference on December 13, 2011
5. Synergy Pharmaceuticals, Inc. Files Suit Against Ironwood Pharmaceuticals, Inc. and its Chief Scientific Officer and Senior VP of R&D, Dr. Mark G. Currie
6. Acumen Pharmaceuticals Regains Worldwide Rights to Anti-ADDL Antibody Therapeutics and Diagnostics for Alzheimers Disease From Merck
7. Inspiration Biopharmaceuticals Moves Corporate Headquarters to Cambridge, Massachusetts
8. Ampio Pharmaceuticals Awarded Canadian Composition of Matter Patent That Strengthens IP Protection for Its Key Drug Ampion™
9. Amylin Pharmaceuticals to Present at the 30th Annual J.P. Morgan Healthcare Conference
10. Inovio Pharmaceuticals Promotes Niranjan Sardesai to Chief Operating Officer
11. Keryx Biopharmaceuticals to Present at JP Morgans 30th Annual Healthcare Conference
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/28/2014)... devices in spintronics, an electronic which is not ... also on their spin and the spin-related magnetism. ... magnetic signals and vice versa. Recently, the research ... of Physics at Johannes Gutenberg University Mainz in ... Japan, has for the first time realised a ...
(Date:8/28/2014)... , Aug. 28, 2014   SunTrust Robinson Humphrey ... industry veterans to its equity research team in ... ongoing expansion in equity research demonstrates our commitment ... insights to enhance their investment decision making," said ... STRH.  "We continue to make significant investments in ...
(Date:8/28/2014)... USA (PRWEB) August 27, 2014 Scientists, ... month for SPIE Laser Damage 2014 symposium. ... materials for high-power lasers will run 14-17 September. The ... for optics and photonics . , The premier conference ... understanding laser damage to optical materials will engage researchers ...
(Date:8/28/2014)... Supplementing their complete line of ... Eppendorf Safe Lock Centrifuge Tubes . This ... quality tubes at an affordable price. Eppendorf Safe ... chemical, medical, pharmaceutical, and life science research and ... able to afford Eppendorf products. , Eppendorf is ...
Breaking Biology Technology:A new, tunable device for spintronics 2A new, tunable device for spintronics 3SunTrust Robinson Humphrey Expands Equity Research in Healthcare and Energy 2SunTrust Robinson Humphrey Expands Equity Research in Healthcare and Energy 3Laser Damage to Draw Researchers, Engineers, Scientists to 46th Annual Conference 2Laser Damage to Draw Researchers, Engineers, Scientists to 46th Annual Conference 3Eppendorf Safe Lock Centrifuge Tube Promotion Now Available at Major Pipette Distributor Pipette.com 2Eppendorf Safe Lock Centrifuge Tube Promotion Now Available at Major Pipette Distributor Pipette.com 3
... - With its recent acquisition of a facility ... has expanded its distribution capabilities to the west ... services for commercial clients, purchased Craftsman Press West, ... distributed magazines, catalogs, and retail inserts. Craftsman Press ...
... - Recently, as I sat at lunch sending off a ... reflect on how our professional lives continue to evolve dramatically, ... the CEO of a company that is driving the adoption ... with how quickly technological change continues to transform and enhance ...
... and global issues going on right now, it could ... issues in yesterday's critical moments. , ,There are ... responsibilities. They are worth applying to your position in ... your view of things. That's very important in today's ...
Cached Biology Technology:Visions: Rimas Buinevicius, CEO of Sonic Foundry 2Visions: Rimas Buinevicius, CEO of Sonic Foundry 3Business leaders can learn from historical insights 2Business leaders can learn from historical insights 3Business leaders can learn from historical insights 4Business leaders can learn from historical insights 5
(Date:8/29/2014)... explored the type and number of connections in transcription ... on robustness in a study published in PLOS ... that the assortativity signature contributes to a network,s resilience ... varying the out-out assortativity of TFN models has a ... other three types of assortativity," said Dov A. Pechenick, ...
(Date:8/29/2014)... of marine phytoplankton, such as the prolific bloomer ... (thiamine), researchers have discovered. The finding contradicts the common ... eukaryotic microbes depend on scarce supplies of thiamine in ... way to think about the ocean," says CIFAR Senior ... ISME Journal paper with CIFAR fellows John ...
(Date:8/29/2014)... - The rise of the Tibetan plateau -- the ... is important for both its profound effect on climate ... published in GSA Bulletin , Katharine Huntington and ... thermometry -- using modern and fossil snail shells to ... southwestern Tibet. , Views range widely on the ...
Breaking Biology News(10 mins):Assortativity signatures of transcription factor networks contribute to robustness 2Not all phytoplankton in the ocean need to take their vitamins 2Not all phytoplankton in the ocean need to take their vitamins 3Snails tell of the rise and fall of the Tibetan Plateau 2Snails tell of the rise and fall of the Tibetan Plateau 3Snails tell of the rise and fall of the Tibetan Plateau 4Snails tell of the rise and fall of the Tibetan Plateau 5Snails tell of the rise and fall of the Tibetan Plateau 6Snails tell of the rise and fall of the Tibetan Plateau 7
... The Netherlands, December 15 WCC Services, the,leading ... announced that,version 6 of its flagship product, ELISE, ... may receive hundreds of applicants for,each job opening ... for the job.,Security concerns are also at peak ...
... Society for Microbiology (ASM) has been honored with non-profit ... its public outreach initiatives. The awards were announced ... Society,s MicrobeWorld Video series received the award for best ... series strives to increase public understanding and appreciation of ...
... GeneVision: the uncanny ability to view the activity of ... modified camera. With GeneVision, military commanders could compare ... track genes related to craving as shoppers moved about ... secret advantage over his love-struck dates. Frightening? Perhaps. ...
Cached Biology News:WCC Announces Version 6 of its ELISE Smart Search and Match Platform for Employment and Biometric Matching 2Real-time gene monitoring developed 2
Assay Diluent, 10 L...
Assay Diluent Trial Pack, 4 x 100 mL...
HRP Monoclonal-Goat Diluent - 5X Concentrate, 25 mL...
SpectroQuest single beam 1.8nm UV/Vis spectrophotometer; stand-alone unit...
Biology Products: