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Sigma-Aldrich and the University of Illinois Offer New Boronic Acid Surrogates to Researchers Worldwide Through Licensing Agreement
Date:10/7/2008

ng weeks. We expect to offer a broad set of these 'off-the-shelf' MIDA synthons, which will enable chemists to rapidly assemble complex chemical architectures using a single palladium-catalyzed reaction."

"This partnership brings together the strengths of a leader in the chemical industry with a first class research university ensuring that both researchers and commercial entities have access to these novel derivatives," stated Eric Payne, technology manager of the Office of Technology Management (OTM), of the University of Illinois at Urbana-Champaign. "We look forward to continuing to partner with Sigma-Aldrich on a wide range of new reagents."

In addition to applications in iterative cross-coupling, MIDA-protected boronic acids (i.e., MIDA boronate esters) have substantially enhanced shelf lives relative to the free boronic acids that often suffer from limited bench top stability. Also, unlike other boronic acid derivatives that may exhibit reduced reactivity relative to their boronic acid counterparts, the MIDA boronate esters are cleaved under exceptionally mild conditions to release the coupling-active boronic acid.

The MIDA technology highlights Sigma-Aldrich's continuing efforts to expand its portfolio of proprietary catalysts, ligands, and organometallic building blocks for use in cross-coupling. Detailed application information on this technology and related products can be found at http://sigma-aldrich.com/mida.

About Sigma-Aldrich: Sigma-Aldrich is a leading Life Science and High Technology company. Its biochemical and organic chemical products and kits are used in scientific and genomic research, biotechnology, pharmaceutical development, the diagnosis of disease and as key components in pharmaceutical and other high technology manufacturing. The Company has customers in life science companies, university and government institutions, hospitals, and in industry. Over on
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