Navigation Links
Sigma-Aldrich Joins Phase 2 of The RNAi Consortium to Validate shRNA Libraries
Date:5/7/2008

Sigma-Aldrich to Provide Full Functional Validation Data for Its MISSION(R)

shRNA Collection

ST. LOUIS, May 7 /PRNewswire-FirstCall/ -- Sigma-Aldrich(TM) (Nasdaq: SIAL) and the second phase of The RNAi Consortium (TRC2) have commenced functional validation of the Consortium's collection of approximately 160,000 previously-cloned lentiviral-based shRNA vector constructs. Currently, more than 5,000 clones have been tested in the functional validation process. Validated clones covering more than 700 genes are available in Sigma-Aldrich's MISSION(R) shRNA collection, a number expected to grow by 75,000 clones per year through 2011. TRC2 will also generate and validate 150,000 additional clones and utilize its collection of validated shRNA libraries to develop new and improved RNAi screening strategies.

Design and development of TRC libraries is led by the Broad Institute of MIT and Harvard. A key goal of the Consortium is to provide at least two clones with a knockdown level of 70% or greater for every human and mouse gene over the next four years. Research will also center on alternative vector development and improved design, with the possible creation of sub-libraries. Functional validation of these knockdown clones will provide significant time and cost savings to researchers by reducing the number of wells to screen, facilitating improved throughput. The total TRC shRNA collection will eventually comprise 300,000 pre-cloned lentiviral-based shRNA vector constructs targeting the human and mouse genomes.

Sigma-Aldrich's MISSION(R) shRNA portfolio is the exclusive source for researchers to access TRC and TRCII shRNA libraries in the plasmid DNA and lentiviral formats. All of the shRNA reagents will be fully functionally validated during phase 2 of The RNAi Consortium. This validation data will be accessible to customers by request, and online, making the MISSION(R) portfolio the only commercially available set of
'/>"/>

SOURCE Sigma-Aldrich
Copyright©2008 PR Newswire.
All rights reserved

0

GOOD

Page: 1 2 3

Related biology technology :

1. Sigma-Aldrich to Present at the Baird 2008 Growth Stock Conference on Tuesday, May 13, 2008
2. Sigma-Aldrich to Present at the Bank of America 2008 Healthcare Conference on Tuesday, May 13, 2008
3. Sigma-Aldrich Announces the Integration of Riedel-De Haen Into Core Product Brands
4. Sigma-Aldrich (Nasdaq: SIAL) Raises 2008 Diluted EPS Forecast by $.05 to $2.57-$2.67. Reports Q1 2008 Diluted EPS Up 14.3%; Sales Gain of 14.9%.
5. Sigma-Aldrich Corporation 1st Quarter 2008 Earnings Conference Call
6. Sigma-Aldrich Partners With Sunset Molecular Discovery to Expand Your Favorite Gene Search Tool
7. Sigma-Aldrich To Hold Annual Business Review
8. Sigma-Aldrich, Oxford BioMedica and Open Biosystems Settle Patent Dispute Over Use of LentiVector Technology in Research Reagents
9. Sigma-Aldrich and MorphoSys Enter Into a Collaboration and Licensing Agreement for Recombinant Research Antibodies
10. Sigma-Aldrich Names Helge Bastian New VP of Global Marketing for Research Biotech
11. Sigma-Aldrich Announces New Prestige Antibodies(TM) Line for Proteomics and Cell Biology Researchers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/19/2008)..., Med Discovery S.A., a S...iary of Validapro Biosciences Inc. have signed a p...ization of protein bioprocess production and scale...EB) November 19, 2008 -- Med Discovery S.A., a Swi...ry of Validapro Biosciences Inc. have signed a par...
(Date:11/19/2008)... LINCOLN, Neb., Nov. 19 LI-COR Bi...sing E-PAGE 48- and 96-well gels the Odyssey Infra...lectrophoresis systems,(Invitrogen Corporation, C...ethod for processing protein samples. When used i...tem, up to 96 different proteins samples can be,e...
(Date:11/19/2008)..., A Michigan-based platfo... revolutionary new artificial intelligence patent ...namically build themselves on a wide variety of co...siness enterprise will be to stimulate the sagging...s of new jobs via subsidiary ventures spawned by t...
(Date:11/19/2008)... ANNAPOLIS, Md., Nov. 19 ...odefense company developing medical,countermeasur...ced today that,it has signed an agreement with Me...e products in Israel. , "The need for advan...,terrorist attacks with biological or chemical wea...
Breaking Biology Technology:Med Discovery and Laborium Biopharma Sign a Bioprocess Development Partnership Agreement 2Technical Note: E-PAGE(TM) 48- and 96-Well Gels on the Odyssey(R) Infrared Imaging System 2Michigan Company Founded upon What Could Be History's Most Important Breakthrough in AI and Robotics 2Michigan Company Founded upon What Could Be History's Most Important Breakthrough in AI and Robotics 3Michigan Company Founded upon What Could Be History's Most Important Breakthrough in AI and Robotics 4PharmAthene Signs Agreement with Medison Pharma Ltd. to Commercialize and Distribute Biodefense Medical Countermeasures in Israel 2PharmAthene Signs Agreement with Medison Pharma Ltd. to Commercialize and Distribute Biodefense Medical Countermeasures in Israel 3PharmAthene Signs Agreement with Medison Pharma Ltd. to Commercialize and Distribute Biodefense Medical Countermeasures in Israel 4
..., , Kathryn L. Dudeck and Wendy A. Dustm...tment of Marine Sciences, , , , ,... This application describes the use of the ...PCR efficiency when studying functional gene prese...ible to amplify a 675 bp region of the amoA , ...
..., , Multiporator , , , , ,...nsfection Protocol , Protocol No. 4308..., , , , , , , ...ransformed human umbilical endothelial cells, , ... Transfection with , pcDNA3-EG...
..., , Multiporator / Electroporator 2510 ,... , Transformation Protocol , ... , , , , , , , ...ganism , Staphylococcus epidermidis, ... Bacteria, gram positive, , ...
..., , Multiporator / Electroporator 2510 ,... , Transformation Protocol , ... , , , , , , , ...ganism , Saccharomyces cerevisiae, ... Yeast, , , Mole...
Other Biology Technology:Amplification of the amoA Gene of Nitrosococcus oceani Bacteria Using , Eppendorf MasterTaq 2Amplification of the amoA Gene of Nitrosococcus oceani Bacteria Using , Eppendorf MasterTaq 3t-HUVEC 2t-HUVEC 3Staphylococcus epidermidis 2Saccharomyces cerevisiae 2
(Date:11/19/2008)... The health threat to city dwellers posed by South...08 may have been underestimated by officials. , ...d by previous California wild fires indicates that...ats to health than is generally realized, accordin... from wildfires in Southern California. , The pa...
(Date:11/19/2008)...S ANGELES -- The National Academy of Sciences (NAS... Entertainment Exchange," an initiative designed t...h top scientists and engineers to help the creator...er productions incorporate science into their work...mal effort to reach out to the entertainment commu...
(Date:11/19/2008)...tober 24, 2008 -- From the collapse of star-formin...rom the combustion of gasoline in your car engine ...dynamics of flight to the concentration of microsc...ascinating phenomena are forms of fluid flow. , ...ociety,s Division of Fluid Dynamics, which takes p...
(Date:11/19/2008)...vember 13, 2008 -- From dolphins to clams to flyin...ture,s most fascinating creatures exhibit forms of...merican Physical Society (APS) Division of Fluid D... Antonio Convention Center, researchers from acros...th applications in astronomy, engineering, alterna...
Breaking Biology News(10 mins):Where there's wildfire smoke, there's toxicity 2NAS announces initiative to connect entertainment industry with top experts 2NAS announces initiative to connect entertainment industry with top experts 3The physics of star-forming clouds and the urban environment 2The physics of star-forming clouds and the urban environment 3The physics of star-forming clouds and the urban environment 4The physics of star-forming clouds and the urban environment 5The physics of star-forming clouds and the urban environment 6Animal and biological science highlights: San Antonio Fluid Dynamics Conference, Nov. 23-25 2Animal and biological science highlights: San Antonio Fluid Dynamics Conference, Nov. 23-25 3Animal and biological science highlights: San Antonio Fluid Dynamics Conference, Nov. 23-25 4Animal and biological science highlights: San Antonio Fluid Dynamics Conference, Nov. 23-25 5Animal and biological science highlights: San Antonio Fluid Dynamics Conference, Nov. 23-25 6Animal and biological science highlights: San Antonio Fluid Dynamics Conference, Nov. 23-25 7Animal and biological science highlights: San Antonio Fluid Dynamics Conference, Nov. 23-25 8National Spokeswoman Eva Longoria Parker to Accept 24200 000 Donation From AT 26T to Benefit PADRES Contra El Cancer 13207 1National Spokeswoman Eva Longoria Parker to Accept 24200 000 Donation From AT 26T to Benefit PADRES Contra El Cancer 13207 2National Spokeswoman Eva Longoria Parker to Accept 24200 000 Donation From AT 26T to Benefit PADRES Contra El Cancer 13207 3National Spokeswoman Eva Longoria Parker to Accept 24200 000 Donation From AT 26T to Benefit PADRES Contra El Cancer 13207 4Pelvic Floor Disorders Affect 1 in 3 Women 13203 1Pelvic Floor Disorders Affect 1 in 3 Women 13203 2UPDATED 3A Catholic Healthcare West and SEIU Begin Negotiations for 15 000 Hospital Workers 13199 1UPDATED 3A Catholic Healthcare West and SEIU Begin Negotiations for 15 000 Hospital Workers 13199 2UPDATED 3A Catholic Healthcare West and SEIU Begin Negotiations for 15 000 Hospital Workers 13199 3Futronic Announces Microsoft Vista and Windows 2008 Server Support for Its Fingerprint Logon Software 2373 1Futronic Announces Microsoft Vista and Windows 2008 Server Support for Its Fingerprint Logon Software 2373 2
...emons, winner of the 2007 Ebbe Nielsen Prize in bi...seum, Sydney. The 2007 Ebbe Nielsen Prize has bee..., Sydney. The Global Biodiversity Information Faci...Ebbe Schmidt Nielsen, who was an inspirational lea...ty informatics. This is the only Prize in the worl...
...p CT scan, composite image of fossil gliding repti... are clearly visible The fossilized bones of a pr..., gliding reptile may remain forever embedded in s...at Penn State,s Center for Quantitative Imaging, t...tures are now known. , The new gliding reptile i...
...rs at the University of Missouri-Columbia are stud...bears were abundant in the state during the 18th a... extinct in Missouri since the late 19th century. ...ssouri Department of Conservation to help manage M... – Kaitlyn Faries, a senior biology and chemistry ...
...evoted husband and father is not enough to keep an...ng-lived seabird found in the Galapagos Islands of... switch mates after successfully raising a chick, ...led for publication in the journal Proceedings of ... , This is surprising because there is an advant...
Other Biology News:Australian wins prestigious prize in biodiversity informatics 2CT scan reveals ancient long-necked gliding reptile 2MU researchers to study the status of black bears in Missouri 2Study investigates 'divorce' among Galapagos seabirds 2
Drugs and NO-drug Rat Anti-conjugated Acetyl Salicylic Acid Polyclonal Antibody
Rabbit polyclonal to UBC12 (rating: ****) ( Abpromise for all tested applications). Antigen: Synthetic peptide: RGGYIGSTYFER, corresponding to amino acids 169-180 of UBC12 Entrez Gene ID: 90
GBL Antibody
Rat Signal Transduction PathwayFinder, PCR Array for expression profiling from SuperArray Bioscience
Biology Products: