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Sigma-Aldrich Introduces MISSION(R) In VIVO QUALITY and iScale Oligos(TM) siRNA, a Superior Quality siRNA Designed for RNAi Research in Animal Models
Date:11/20/2008

ST. LOUIS, Nov. 20 /PRNewswire-FirstCall/ -- Sigma-Aldrich (Nasdaq: SIAL) announced today the global release of MISSION(R) In VIVO QUALITY and iScale Oligos(TM) siRNA. MISSION(R) In VIVO QUALITY and iScale Oligos(TM) siRNA are expected to allow researchers to successfully take the next step in their RNAi research with the highest purity and quality siRNA required for RNAi research in animal models. These siRNA are believed to be well suited to target validation and pre-clinical siRNA testing. Intermediate and large synthesis scales and a wide variety of modifications are also available.

"Increasingly, RNAi researchers are utilizing animal models to confirm findings from cell culture based assays or to explore the use of siRNA as a potential therapeutic agent," said Tim Fleming, Director of Global Commercial Marketing at Sigma-Aldrich. "Our goal is to provide an siRNA that is capable of facilitating in vivo siRNA research, with the purity levels required for direct delivery or to be used as an essential part of an overall in vivo formulation strategy."

MISSION(R) In VIVO QUALITY siRNA are processed specifically for in vivo usage. This purification process includes RP-HPLC to ensure a high percentage of full-length product (>94%), dialysis on the annealed product to remove excess salts, 22 micrometer sterile filtration, and finally testing to ensure no endotoxins are present.

In addition, iScale Oligos(TM) synthesis scales can give customers the large quantities of siRNA required for in vivo usage with amounts up to 100mg. MISSION(R) In VIVO QUALITY and iScale Oligos(TM) siRNA are available with many of the common modifications used to for tracking or stability, such as FAM, Cy5(TM), and Cy3(TM).

"Sigma-Aldrich's MISSION(R) In VIVO QUALITY siRNAs are used exclusively at BIOO Scientific(TM) for all of our internal in vivo formulation development programs," said Lance Ford, Vice President of Research and Development at BIOO Scientific(TM) Corporation. "Most recently, we have used these siRNAs to with great success to demonstrate the utility of our new in vivo formulation, MaxSuppressor(TM) In Vivo RNA-LANCEr II (catalog #3410-01), in mouse models. BIOO Scientific(TM) Corporation recommends these siRNAs to our all of our customers as they are exceptional siRNAs, offered at a competitive price, with rapid turnaround times and supported by Sigma-Aldrich's professional service."

For more information on the MISSION(R) In VIVO QUALITY and iScale Oligos(TM) siRNA, please visit sigma-aldrich.com/invivosirna .

About Sigma-Aldrich: Sigma-Aldrich is a leading Life Science and High Technology company. Our biochemical and organic chemical products and kits are used in scientific and genomic research, biotechnology, pharmaceutical development, the diagnosis of disease and as key components in pharmaceutical and other high technology manufacturing. We have customers in life science companies, university and government institutions, hospitals, and in industry. Over one million scientists and technologists use our products. Sigma-Aldrich operates in 36 countries and has 8,000 employees providing excellent service worldwide. Sigma-Aldrich is committed to Accelerating Customer Success through Leadership in Life Science, High Technology and Service. For more information about Sigma-Aldrich, please visit our award-winning website at http://www.sigma-aldrich.com.


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