Sigma-Aldrich(R) and Sangamo BioSciences Announce Major Expansion of ZFP Technology License... (l of $25.0 million based upon cumulative...)

Sigma-Aldrich(R) and Sangamo BioSciences Announce Major Expansion of ZFP Technology License Agreement

Date:10/5/2009

l of $25.0 million, based upon cumulative product sales.

About Sigma-Aldrich

Sigma-Aldrich is a leading Life Science and High Technology company. Its biochemical and organic chemical products and kits are used in scientific and genomic research, biotechnology, pharmaceutical development, the diagnosis of disease and as key components in pharmaceutical and other high technology manufacturing. The Company has customers in life science companies, university and government institutions, hospitals, and in industry. Over one million scientists and technologists use its products. Sigma-Aldrich operates in 38 countries and has 7,800 employees providing excellent service worldwide. Sigma-Aldrich is committed to Accelerating Customer Success through Innovation and Leadership in Life Science, High Technology and Service. For more information about Sigma-Aldrich, please visit its award-winning Web site at http://www.sigma-aldrich.com.

About Sangamo

Sangamo BioSciences, Inc. is focused on the research and development of novel DNA-binding proteins for therapeutic gene regulation and modification. The most advanced ZFP Therapeutic(TM) development program is currently in Phase 2 clinical trials for evaluation of safety and clinical effect in patients with diabetic neuropathy and ALS. Sangamo also has two Phase 1 clinical trials to evaluate safety and clinical effect of a ZFP Therapeutic for the treatment of HIV/AIDS. Other therapeutic development programs are focused on cancer, neuropathic pain, nerve regeneration, Parkinson's disease and monogenic diseases. Sangamo's core competencies enable the engineering of a class of DNA-binding proteins known as zinc finger DNA-binding proteins (ZFPs). By engineering ZFPs that recognize a specific DNA sequence Sangamo has created ZFP transcription factors (ZFP TF) that can control gene expression and, consequently, cell function. S
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... ,Components g/500 ml: ,Tryptone ... chloride 2.5 ,Agar 6.0 ,S-Gal ... ,IPTG 0.025 ,Kanamycin 0.0175 ... complete growth medium containing S-Gal ...

Useful for determination of glucose and ATP. Packaging: Package sizes are based on hexokinase units. Preparation Unit Definition: One unit will phosphorylate 1.0 mol of D -glucose per min at pH ...

Biology Products:

Bio-Stack Twister II Microplate Handler from BioTek Instruments S-Protein Agarose from Novagen S-Gal/LB Agar/Kanamycin Blend from Sigma-Aldrich Baker's yeast (S. cerevisiae) Hexokinase and glucose-6-phosphate dehydrogenase from Sigma-Aldrich

Sigma-Aldrich(R) and Sangamo BioSciences Announce Major Expansion of ZFP Technology License...(l of $25.0 million based upon cumulative...)