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Sigma-Aldrich (Nasdaq: SIAL) Reports Q4 and Full Year 2010 Diluted EPS of $0.76 and $3.12, Respectively. Q4 and Full Year 2010 Adjusted Diluted EPS Were $0.83 and $3.31, Respectively. Q4 Sales Set New Quarterly High. 2011 Diluted EPS Expected to be
Date:2/9/2011

sh Flows (Unaudited)(in millions)Twelve MonthsEnded December 31,20102009Cash flows from operating activities:Net income

$
384$
347Adjustments to reconcile net income to net cash provided by operating activities:Depreciation and amortization

9392Deferred income taxes

(2)(7)Stock-based compensation expense

2217Restructuring costs, net of payments

159Impairment charge

7-Other

(7)3Changes in operating assets and liabilities:Accounts receivable

1(9)Inventories

871Accounts payable

8(5)Income taxes

(12)(5)Other, net

63Net cash provided by operating activities

523516Cash flows from investing activities:Capital expenditures

(99)(120)Purchases of short-term investments

(43)(25)Proceeds from sale of short-term investments

418Purchases of technology

-(19)Acquisitions of businesses, net of cash acquired

(80)(6)Other, net

(1)2Net cash used in investing activities

(182)(160)Cash flows from financing activities:Net repayment of short-term debt

(238)(135)Issuance of long-term debt

298-Repayment of long-term debt

(100)(7)Payment of dividends

(78)(71)Treasury stock purchases

(99)(67)Proceeds from exercise of stock options

4524Excess tax benefits from stock-based payments

116Net cash used in financing activities

(161)(250)Effect of exchange rate changes on cash1615Net change in cash and cash equivalents196121Cash and cash equivalents at January 1373252Cash and cash equivalents at December 31$
569$
373Free cash flow(1)$
424$
396(1)
Net cash provided by operating activities less capital expenditures.SIGMA-ALDRICH CORPORATIONSupplemental Financial Information - (Unaudited)Sales Growth by Business UnitThree MonthsEnded December 31, 2010CurrencyAdjustedReportedImpact(Organic)   Research Essen
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1. Sigma-Aldrich to Present at the JP Morgan 29th Annual Healthcare Conference on Monday, January 10, 2011.
2. Sigma-Aldrich Acquires Cerilliant Corporation to Strengthen its Analytical Chemistry Portfolio
3. Sigma-Aldrich Corporation Announces Death of Chairman and CEO; Election of New CEO and Chairman; Conference Call Scheduled for 10:00a.m. (Central Time) on November 15, 2010
4. Sigma-Aldrich Announces Pricing of Senior Notes
5. Sigma-Aldrich (Nasdaq: SIAL) Reports Q3 2010 Diluted EPS of $0.76. Diluted EPS Increased by 9% and 19% on a Reported and Adjusted Basis, Respectively. Q3 Sales Performance Remains Strong; Full Year 2010 Diluted Adjusted EPS Outlook Raised to $3.20 -
6. Sigma-Aldrich to Present at the UBS Global Life Sciences Healthcare Conference on Tuesday, September 21, 2010
7. Sigma-Aldrich Announces Appointment of Magnus Borg as Vice President and Chief Information Officer (CIO)
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9. Sigma-Aldrich (Nasdaq: SIAL) Announces Executive Management Changes: Retirement of David Julien and Promotion of Joseph Porwoll
10. Sigma-Aldrich to Present at the Bank of America Merrill Lynch 2010 Health Care Conference on Wednesday, May 12, 2010
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