Navigation Links
Sigma® Life Science and Kraig Biocraft Laboratories to Develop Silkworms for the Production of Spider Silk
Date:4/12/2011

ST. LOUIS, April 12, 2011 /PRNewswire/ -- Sigma Life Science, the innovative biological products and services research business of Sigma-Aldrich® (Nasdaq: SIAL), today announced the signing of an agreement with Kraig Biocraft Laboratories, Inc. (KBLB) to develop genetically modified silkworms for the production of spider silk, using Sigma's proprietary CompoZr Zinc Finger Nuclease (ZFN) technology. The transfer of silk genes from the spider to the silkworm is expected to allow the mass production of silk with enhanced strength and elasticity with potential textiles and biomedical applications, such as sutures, tendon and ligament repair, bulletproof vests, and automobile airbags.

Since the first published sequence of a spider silk gene in 1990, much research has focused on the production of commercially viable spider silk with high tensile strength and elasticity. In 2010 KBLB made an important advance towards this goal, by producing hybrid silkworms with randomly inserted spider silk genes, yielding hybrid spider­silkworm silk with greater strength and durability than native silkworm silk. The precise gene targeting and high efficiency of Sigma's ZFN technology allows KBLB to build on its revolutionary proof of concept research, by concomitantly targeting the insertion of spider silk genes into the silkworm genome while removing endogenous silkworm silk genes. The resulting transgenic silkworm is expected to be capable of spinning pure spider silk at commercially viable production levels.

"ZFN technology has been revolutionary in genome engineering for various applications, including animal models of disease, engineering of biopharmaceutical production systems, academic research and therapeutics," said Dr. Joseph Bedell, Director of Sigma Life Science's Commercial Animal Technologies Group. "Spider silk production is just the first example of a poten
'/>"/>

SOURCE Sigma Life Science
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related biology technology :

1. Sigma® Life Science Joins AMDeCs Vendor Partnership Program, Further Enhancing Value to Academic Medical Research Centers
2. Sigma® Life Science Launches Suite of Knockout Rats to Model Parkinsons Disease
3. Sigma® Life Science Launches Pre-designed CompoZr® Knockout Zinc Finger Nucleases for Entire Human Genome
4. Sigma® Life Science Creates Worlds First Knock-in Rats using Zinc Finger Nuclease Technology
5. Sigma® Life Science Awarded Silver in Top Ten Innovations 2010
6. Sigma® Life Science Enters Genetically Modified Cell Market
7. Magellan Biosciences and Miacom Diagnostics Team Up to Enable Faster, Easier Identification of Pathogens as Part of Magellans End-to-End Suite of Microbiology Products Designed to Streamline Lab Workflow and Enable Better Treatment Decisions
8. QB3, Deloitte Collaborate To Drive California Bioscience Innovation
9. Neurocrine Biosciences Announces Successful Phase IIa Clinical Trial for VMAT2 Inhibitor
10. Sangamo BioSciences and CHDI Foundation Announce Collaboration to Develop ZFP Therapeutic® for Huntingtons Disease
11. BioSpace Highlights North Carolinas Life Science Regions
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/23/2014)... York , September 23, 2014 ... leading provider of  Closed System Transfer     Devices ... exclusive partnership with Taiwanese distributor MedFront Medical Technology Corporation.  Equashield,s ... in Taiwan , ... as the company continues to expand globally, and ...
(Date:9/23/2014)... 23, 2014 Dr. Williams says, “Find ... on healthcare offers a three phase process that can ... delivery system that would go far beyond anything previously ... the delivery of healthcare.” , “Every effort to improve ... to provide discernable progress throughout that system because all ...
(Date:9/23/2014)... England , September 23, 2014 ... launched with funding from Imperial Innovations, Cambridge Innovation Capital ... Inivata, a clinical cancer genomics company focused on ... analysis to improve cancer testing and treatment, today ... round led by Imperial Innovations and including Cambridge ...
(Date:9/22/2014)... and SANTA CLARA, Calif. , Sept. ... WBMD ), the leading source of health information, ... survey that provide novel insights regarding physician and ... and care.  Dr. Eric Topol , a leading ... who serves as both Editor-in-Chief of Medscape and Chief ...
Breaking Biology Technology:Equashield Enters Taiwan Following Expansion to Australia, Japan, China 2Dr. Ira Williams Offers the Healthcare Solution Necessary for Patient Safety Improvement 2Inivata Raises £4m to Realise the Potential of ctDNA Analysis to Improve Cancer Treatment Through Simple Blood Tests 2Inivata Raises £4m to Realise the Potential of ctDNA Analysis to Improve Cancer Treatment Through Simple Blood Tests 3Inivata Raises £4m to Realise the Potential of ctDNA Analysis to Improve Cancer Treatment Through Simple Blood Tests 4WebMD/Medscape Digital Technology Survey Reveals Unique Insights Into How Patients and Physicians Perceive the Role, Potential and Risks Associated with Digital Health Technologies 2WebMD/Medscape Digital Technology Survey Reveals Unique Insights Into How Patients and Physicians Perceive the Role, Potential and Risks Associated with Digital Health Technologies 3WebMD/Medscape Digital Technology Survey Reveals Unique Insights Into How Patients and Physicians Perceive the Role, Potential and Risks Associated with Digital Health Technologies 4
... Bowl MVP,s; 94 NFL First Round Draft Picks; ... ... BASKING RIDGE, N.J., Feb. 8 Millennium,Biotechnologies Inc., wholly-owned subsidiary ... SURGEX(TM) is,currently being administered as the exclusive post workout nutritional,product provided ...
... Calif., Feb. 8 Genomic Health,Inc. (Nasdaq: GHDX ... Chief Operations Officer, will present at the BIO CEO ... 2008 at 10:15 a.m. Eastern,Time., To access the ... Investor Relations section of Genomic Health,s,website at http://investor.genomichealth.com ...
... available in Spanish . , ANN ARBOR, ... from walking to operate a portable GPS locator, a ... neurotransmitter, research involving the University of Michigan shows. , ... Feb. 8 issue of the journal Science. Authors include ...
Cached Biology Technology:Tom Shaw's NFL Training Center Chooses SURGEX(TM) as Their Exclusive Post Training Nutritional Regimen 2Tom Shaw's NFL Training Center Chooses SURGEX(TM) as Their Exclusive Post Training Nutritional Regimen 3Knee brace generates electricity from walking 2
(Date:9/23/2014)... Rice University scientists who are fighting a cyberwar against ... clinician,s most powerful ally. , "Recent research has found ... the immune system, and we studied the interplay between ... might turn the tables on cancer," said Rice University,s ... in the Early Edition of the Proceedings of ...
(Date:9/23/2014)... the washing up, negotiating rights to the TV remote control ... university for the new academic year are about to learn ... business. , And now research from academics at The University ... to monitor their energy usage in the home could be ... a team of technology experts and psychologists found that meters ...
(Date:9/23/2014)... 2014 Research and Markets  has announced ... and Opportunities, 2019" report to their offering. ... enhancing security and protection in private as well as ... country,s government is focusing on using biometric systems to ... national IDs that are of crucial importance to the ...
Breaking Biology News(10 mins):Immune system is key ally in cyberwar against cancer 2Immune system is key ally in cyberwar against cancer 3Smart meters could cause conflict for housemates, study shows 2Smart meters could cause conflict for housemates, study shows 3India Biometrics Market Forecast and Opportunities, 2019 2India Biometrics Market Forecast and Opportunities, 2019 3
... Military, homeland security, law enforcement and other first-responder ... to attend the 2009 Force Protection Equipment Demonstration ... 600 exhibits will be presented at Stafford County ... Quantico, VA. Live-fire small arms and explosives survivability ...
... Technology (Caltech) and the University of California at San ... Caltech experimental data to show just how amino-acid chains ... Their insights were recently published in the February 10 ... of Sciences (PNAS). The paper details the ...
... human genome eight years ago, enormous progress has been ... of most human genes is still barely understood. An ... gene or protein is to compare its sequence with ... experimentally easier to investigate. From the functions of related ...
Cached Biology News:Demonstration Targets Terrorism 2Caltech and UCSD researchers shed light on how proteins find their shapes 2Relationships in rank and file 2Relationships in rank and file 3Relationships in rank and file 4
... service provides the premium quality siRNAs you ... siRNAs can be readily ordered online by ... or by providing the sense and antisense ... Silencer Validated and Silencer ...
... custom siRNA service provides the premium quality ... research. Custom siRNAs can be readily ordered ... target sequence, or by providing the sense ... Ambion's Silencer Validated and ...
dithiothreitol, sulfhydryl reducing agent, C4H10O2S2; MW: 154.24, 97% pure (minimum), CAS No: 27565-41-9, store at -20 C ...
... NAP-10 Columns, 50. For rapid and ... 10-mers) in less than 15 minutes by ... in distilled water containing 0.15% Kathon CG/ICP ... volume: 0.5 ml (NAP-5), 1 ml ...
Biology Products: