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Sigma® Life Science Launches Pre-designed CompoZr® Knockout Zinc Finger Nucleases for Entire Human Genome
Date:2/24/2011

ST. LOUIS, Feb. 24, 2011 /PRNewswire/ -- Sigma Life Science, the innovative biological products and services research business of Sigma-Aldrich® (Nasdaq: SIAL), today announced the release of its pre-designed CompoZr Knockout Zinc Finger Nucleases (ZFNs) technology to knockout any gene in the human genome.  The new offer, attractively priced to fit within the budget of a typical laboratory, can generate permanent and heritable gene knockouts in human cell lines within weeks.  For more detailed information, visit www.wherebiobegins.com/knockout.

Currently, few laboratories create gene knockouts in human cell lines due to the inefficiencies of the natural cellular homologous recombination system and the investment of time and labor required to screen the resulting cells.  In contrast, a wealth of peer-reviewed literature has shown that CompoZr ZFNs efficiently generate human cell lines with precise and stable gene knockouts in a matter of weeks.(1)

"Sigma Life Science has worked diligently to develop predesigned CompoZr Knockout ZFNs for each gene in the human genome to make this ground breaking technology more readily available to the research community," said David Smoller, Chief Scientific Officer of Sigma Life Science.  "Researchers can select a ZFN from our library and swiftly knockout their target gene in any human cell line."

In this new offering, Sigma has designed CompoZr ZFNs that will produce a knockout in each gene by inducing a double-strand break at a defined site within the gene's first three exons.  This double strand break stimulates the cell's natural DNA repair pathways, resulting in a permanent, site-specific deletion or mutation that disrupts the gene's function.  Robust and on-target gene knockout using CompoZr Knockout ZFNs is guaranteed by functional val
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