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Sigma® Life Science Creates World's First Knock-in Rats using Zinc Finger Nuclease Technology
Date:12/13/2010

ted mutations, and this breakthrough from SAGE™ Labs puts ZFN technology on par with classic ES cell-based gene targeting techniques in terms of application flexibility. SAGE Labs will use this technology, combined with its SAGEspeed™ model creation process, to produce a number of off-the-shelf rat models for use in the study of human diseases, as well as custom models for customers.

"We have invested time and resources in developing the CompoZr and SAGEspeed platforms to help realize the enormous potential of this technology, enabling precise manipulation of the genome of living organisms," said Dr. Edward Weinstein, Director of SAGE Labs at Sigma Life Science. "This exciting advance is another example of how Sigma Life Science is pushing the limits of technology, establishing what we believe will become the new standard for the creation of genetically engineered research animals."

For more information on SAGE Labs, please visit http://www.sageresearchmodels.com.

Cautionary statement: The foregoing release contains forward-looking statements that can be identified by terminology such as "represent a major step," "may serve," "opens the doors," "will become" or similar expressions, or by expressed or implied discussions regarding potential future revenues from products derived therefrom. You should not place undue reliance on these statements. Such forward-looking statements reflect the current views of management regarding future events, and involve known and unknown risks, uncertainties and other factors that may cause actual results to be materially different from any future results, performance or achievements expressed or implied by such statements. There can be no guarantee that knock-in rats will achieve any particular levels of revenue in the future. In particular, management's expectations regarding knock-in rats could be affected by, among other things, unexpected regu
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