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Shire's Replenished Portfolio Drives Excellent Quarterly Performance
Date:4/29/2010

ernational presence and building on our recent product launches. We are also progressing our pipeline and we expect to deliver further newsflow on our early projects later this year. Our core products are leveraging our existing infrastructure and we will continue to expand our operating margins.

Our performance in the first quarter reinforces our confidence in growing both revenue and earnings in the full year 2010 compared to 2009, and we re-iterate our aspirational target of mid-teens revenue growth on average between 2009 and 2015."

    FINANCIAL SUMMARY
    First Quarter 2010 Unaudited Results

                            Q1 2010                         Q1 2009
                                           Non                            Non
                US GAAP   Adjustments     GAAP  US GAAP   Adjustments    GAAP
                     $M            $M       $M       $M            $M      $M
    Revenues        816             -      816      818             -     818
    Operating
    income          218            47      265      226           101     327

    Diluted
    earnings
    per ADS       $0.89         $0.12    $1.01    $1.16         $0.12   $1.28

The Non GAAP financial measures included within this release are explained on pages 19 and 20, and are reconciled to the most directly comparable financial measures prepared in accordance with US GAAP on pages 17 and 18.

    - Product sales from core products were up 36% to $626 million (2009:
      $460 million). On a constant exchange rate ("CER") basis, which is a
      Non GAAP measure, core product sales were up 33%. Growth in core
      product sales was achieved by strong performance throughout the
      portfolio including:

    - VYVANSE(R) (up 32% to $154 million, CER: up 32%);

    - ELAPRASE(R) (up 22% to $101 million, CER: up 17%);

    - REPLAGAL(R) (up 69% to $68 million, CER: up 60%);

    - LI
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SOURCE  Shire plc
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