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Shire's Replenished Portfolio Drives Excellent Quarterly Performance
Date:4/29/2010

areholders, including Shire. The remaining consideration was released from escrow in March 2010, resulting in a gain of $11.1 million being recognized in Q1 2010.

Taxation

The effective rate of tax for the three months to March 31, 2010 was 24% (2009: 19%), and the effective tax rate on Non GAAP income was 26% (2009: 24%).

The Non-GAAP effective tax rate in 2010 is higher than the same period in 2009 due to unfavourable changes in profit mix and the recording of valuation allowances in 2010 in relation to loss carry forward amounts which were not recorded in Q1 2009.

    FINANCIAL INFORMATION
    TABLE OF CONTENTS

                                                          Page

    Unaudited US GAAP Statement of Financial Position       11

    Unaudited US GAAP Consolidated Statements of
    Operations                                              12

    Unaudited US GAAP Consolidated Statements of Cash
    Flows                                                   14

    Selected Notes to the Unaudited US GAAP Financial
    Statements
    (1) Earnings per share                                  15
    (2) Analysis of revenues                                16

    Non GAAP reconciliation                                 17

    Unaudited US GAAP results for the three months to March 31, 2010
Consolidated Balance Sheets

                                                       March 31, December 31,
                                                            2010         2009
                                                              $M           $M
    ASSETS
    Current assets:
    Cash and cash equivalents                              657.5        498.9
    Restricted cash                                         26.8         33.1
    Accounts receivable, net
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SOURCE Shire plc
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