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Shire's Replenished Portfolio Drives Excellent Quarterly Performance
Date:4/29/2010

authorized generic versions of ADDERALL XR by Teva and Impax in April and October 2009, and the inclusion of lower margin sales of the authorized generic to Teva and Impax which depressed gross margins for ADDERALL XR.

    Research and development ("R&D")

                                              % of                  % of
                                           product               product
                              Q1 2010        sales  Q1 2009        sales
                                   $M                    $M
    R&D (US GAAP)               131.0          18%    185.9          25%
    Women's Health exit costs       -                (65.0)
    Depreciation                (3.7)                 (4.0)
    R&D (Non GAAP)              127.3          18%    116.9          15%

Non GAAP R&D increased in absolute terms by $10.4 million in 2010 over 2009 due to continued increased investment in R&D programs, in part as a result of acceleration of the REPLAGAL and VPRIV programs. As a percentage of core product sales, Non GAAP R&D decreased by 5 percentage points to 20% (2009: 25%).

    Selling, general and administrative ("SG&A")

                                            % of              % of
                                         product           product
                                Q1 2010    sales  Q1 2009    sales
                                     $M                $M
    SG&A (US GAAP)                359.9      50%    318.9      42%
    Intangible asset             (34.6)            (32.5)
    amortization
    Depreciation                 (16.3)            (14.8)
    SG&A (Non GAAP)               309.0      43%    271.6      36%

Non GAAP SG&A increased in 2010 compared to 2009 due in part to increased selling and marketing costs incurred in
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SOURCE Shire plc
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