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Shire's Quarterly Revenues Grow by 25% to $1 Billion for the First Time
Date:7/28/2011

2 40% 9% PENTASA 130.3 118.8 10% 6% RESOLOR 2.5 - n/a <1% 319.1 252.0 27% 16% Regenerative Medicine DERMAGRAFT 2.0 - n/a <1% 2.0 - n/a <1% General products FOSRENOL 86.5 92.1 -6% 4% XAGRID 45.9 45.0 2% 2% CARBATROL 33.3 43.1 -23% 2% 165.7 180.2 -8% 8% Other product sales 47.7 54.8 -13% 2% Total SP product sales 1,292.8 1,092.6 18% 64% HGT ELAPRASE 231.3 200.6 15% 11% REPLAGAL 225.3 149.9 50% 11% VPRIV 122.3 34.5 254% 6% FIRAZYR 10.9 4.8 127% <1% Total HGT product sales 589.8 389.8 51% 29% Total product sales 1,882.6 1,482.4 27% 93% Royalties: 3TC and ZEFFIX 46.8 74.7 -37% 2% ADDERALL XR 43.7 68.3 -36% 2% FOSRENOL 20.5 11.1 85% 1% Other 26.0 23.9 9% 1% Total royalties 137.0 178.0 -23% 6% Other revenues 15.5 5.1 204% 1% Total Revenues 2,035.1 1,665.5 22% 100%

Unaudited results for the three months to June 30, 2011

Non GAAP reconciliation

US GAAP Adjustments Acquisitions Divestments, Amortization & reorganizations & asset integration & discontinued 3 months to, June 30, impairments activities operations 2011 (a) (b) (c) $M $M $M $M Total revenues 1,062.9 - - - Costs and expenses: Cost of product sales 143.7 - - (2.8) Research and development 176.9 - - - Selling, general and administrative 440.3 (36.7) - - Loss on sale of product rights 2.2 - - (2.2) Reorganization costs 7.5 - - (7.5) Integration and acquisition costs 9.0 - (9.0) - Depreciation - - - - Total operating expenses 779.6 (36.7) (9.0) (12.5) Operating income 283.3 36.7 9.0 12.5 Interest income 0.6 - - - Interest expense (9.9) - - - Total other expense, net (9.3) - - - Income before income taxes and equity in earnings of equity method investees 274.0 36.7 9.0 12.5 Income taxes (69.7) (3.9) (1.1) (2.4) Equity in earnings of equity method investees, net of tax 1.2 - - - Net income 205.5 32.8 7.9 10.1 Impact of convertible debt, net of tax 8.4 - - - Numerator for diluted EPS 213.9 32.8 7.9 10.1 Weighted average number of shares (millions) - diluted 595.
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SOURCE Shire plc
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