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Shire's Quarterly Revenues Grow by 25% to $1 Billion for the First Time
Date:7/28/2011

of diluted EPS because (a) their exercise prices exceeded Shire plc's average share price during the calculation period or (b) satisfaction of the required performance/market conditions cannot be measured until the conclusion of the performance period.

Unaudited US GAAP results for the three months to June 30, 2011

Selected Notes to the Financial Statements

(2)  Analysis of revenues

3 months to June 30, 2011 2010 2011 2011 % % of total $M $M change revenue Net product sales: SP ADHD VYVANSE 185.9 148.0 26% 17% ADDERALL XR 146.9 80.4 83% 14% INTUNIV 59.6 51.2 16% 6% EQUASYM 5.9 8.2 -28% <1% DAYTRANA - 16.3 n/a n/a 398.3 304.1 31% 37% GI LIALDA/MEZAVANT 99.2 69.6 43% 9% PENTASA 65.8 60.6 9% 6% RESOLOR 1.6 - n/a <1% 166.6 130.2 28% 16% Regenerative Medicine DERMAGRAFT 2.0 - n/a <1% 2.0 - n/a <1% General products FOSRENOL 45.3 45.1 - 4% XAGRID(R) 23.2 21.6 7% 2% CARBATROL(R) 16.7 23.0 -27% 2% 85.2 89.7 -5% 8% Other product sales 24.6 27.3 -10% 2% Total SP product sales 676.7 551.3 23% 64% HGT ELAPRASE 127.8 99.8 28% 12% REPLAGAL 119.9 81.9 46% 11% VPRIV 63.3 28.7 121% 6% FIRAZYR 5.6 2.6 115% <1% Total HGT product sales 316.6 213.0 49% 29% Total product sales 993.3 764.3 30% 93% Royalties: ADDERALL XR 26.9 27.5 -2% 3% FOSRENOL 12.4 6.0 107% 1% 3TC and ZEFFIX 11.3 38.1 -70% 1% Other 12.8 11.1 15% 1% Total royalties 63.4 82.7 -23% 6% Other revenues 6.2 2.4 158% 1% Total Revenues 1,062.9 849.4 25% 100%

Unaudited US GAAP results for the six months to June 30, 2011

Selected Notes to the Financial Statements

(2)  Analysis of revenues

6 months to June 30, 2011 2010 2011 2011 % % of total $M $M change revenue Net product sales: SP ADHD VYVANSE 388.2 302.4 28% 19% ADDERALL XR 258.1 172.2 50% 13% INTUNIV 101.5 85.7 18% 5% EQUASYM 10.5 10.6 -1% <1% DAYTRANA - 34.7 n/a n/a 758.3 605.6 25% 37% GI LIALDA/MEZAVANT 186.3 133.
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SOURCE Shire plc
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