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Shire's Quarterly Revenues Grow by 25% to $1 Billion for the First Time
Date:7/28/2011

sed compensation 9.8 (0.4) 18.8 4.4 Proceeds from exercise of options 0.6 0.4 0.8 1.8 Payment of dividend (60.5) (49.8) (60.5) (49.8) Payments to acquire shares by ESOT (63.9) (1.7) (63.9) (1.7) Net cash used in financing activities(C) (97.3) (95.3) (88.3) (89.7) Effect of foreign exchange rate changes on cash and cash equivalents (D) 0.3 4.1 2.7 6.1 Net (decrease)/increase in cash and cash equivalents(A) +(B) +(C) +(D) (567.4) 25.0 (406.0) 183.6 Cash and cash equivalents at beginning of period 712.0 657.5 550.6 498.9 Cash and cash equivalents at end of period 144.6 682.5 144.6 682.5

Unaudited US GAAP results for the three months and six months to June 30, 2011

Selected Notes to the Financial Statements

   (1)  Earnings per share

3 months to 3 months to 6 months to 6 months to June 30, June 30, June 30, June 30, 2011 2010 2011 2010 $M $M $M $M Numerator for basic EPS 205.5 160.5 416.8 326.2 Interest on convertible bonds, net of tax 8.4 8.4 16.8 16.8 Numerator for diluted EPS 213.9 168.9 433.6 343.0 Weighted average number of shares: Millions Millions Millions Millions Basic(1) 552.3 546.6 551.1 545.7 Effect of dilutive shares: Stock options(2) 9.3 10.2 10.3 10.2 Convertible bonds 2.75% due 2014(3) 33.5 33.2 33.4 33.2 Diluted 595.1 590.0 594.8 589.1

(1) Excludes shares purchased by ESOT and presented by Shire as treasury stock.

(2)Calculated using the treasury stock method.

(3) Calculated using the "if converted" method.

The share equivalents not included in the calculation of the diluted weighted average number of shares are shown below:

3 months to 3 months to 6 months to 6 months to June 30, June 30, June 30, June 30, 2011 2010 2011 2010 Millions Millions Millions Millions Share awards(1) 2.9 8.1 3.8 8.1

(1)Certain stock options have been excluded from the calculation
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SOURCE Shire plc
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