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Shire's Quarterly Revenues Grow by 25% to $1 Billion for the First Time
Date:7/28/2011

(17.3) Other (expense)/income, net - (2.6) 0.3 8.2 Total other expense, net (9.3) (10.4) (17.6) (8.3) Income before income taxes and equity in earnings of equity method investees 274.0 214.0 532.2 433.8 Income taxes (69.7) (54.5) (117.8) (108.1) Equity in earnings of equity method investees, net of taxes 1.2 1.0 2.4 0.5 Net income 205.5 160.5 416.8 326.2

(1)Cost of product sales includes amortization of intangible assets relating to favorable manufacturing contracts of $0.4 million for the three months to June 30, 2011 (2010: $0.4 million) and $0.9 million for the six months to June 30, 2011 (2010: $0.9 million). SG&A costs include amortization of intangible assets relating to intellectual property rights acquired of $36.7 million for the three months to June 30, 2011 (2010: $33.8 million) and $72.7 million for the six months to June 30, 2011 (2010: $68.4 million).

Unaudited US GAAP results for the three months and six months to June 30, 2011
Consolidated Statements of Income (continued)

3 months to 3 months to 6 months to 6 months to June 30, June 30, June 30, June 30, 2011 2010 2011 2010 Earnings per ordinary share - basic 37.2c 29.4c 75.7c 59.8c Earnings per ADS - basic 111.6c 88.2c 227.1c 179.4c Earnings per ordinary share - diluted 35.9c 28.6c 72.9c 58.2c Earnings per ADS - diluted 107.7c 85.8c 218.7c 174.6c Weighted average number of shares: Millions Millions Millions Millions Basic 552.3 546.6 551.1 545.7 Diluted 595.1 590.0 594.8 589.1

Unaudited US GAAP results for the three months and six months to June 30, 2011
Consolidated Statements of Cash Flows

3 months 3 months 6 months 6 months to to to to June 30, June 30, June 30, June 30, 2011 2010 2011 2010 $M $M $M $M CASH FLOWS FROM OPERATING ACTIVITIES: Net income 205.5 160.5 416.8 326.2 Adjustments to reconcile net income to net cash provided by operating activities: Depreciation and amortiz
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