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Shire's Quarterly Revenues Grow by 25% to $1 Billion for the First Time
Date:7/28/2011

epresented 93% of total revenues (Q2 2010: 90%).

Product Highlights

US Exit Market Year on year growth Share(1) Product Sales $M Sales CER US Rx(1) VYVANSE 185.9 +26% +25% +21% 15% ADDERALL XR 146.9 +83% +82% +16% 8% ELAPRASE(R) 127.8 +28% +20% n/a(2) n/a(2) REPLAGAL 119.9 +46% +32% n/a(3) n/a(3) LIALDA / MEZAVANT 99.2 +43% +41% +8% 20% PENTASA(R) 65.8 +9% +9% -3% 15% VPRIV 63.3 +121% +110% n/a(2) n/a(2) INTUNIV 59.6 +16% +16% +88% 4% FOSRENOL(R) 45.3 +0% -5% -13% 6% FIRAZYR 5.6 +115% +89% n/a(3) n/a(3) DERMAGRAFT 2.0 n/a n/a n/a n/a RESOLOR 1.6 n/a n/a n/a(3) n/a(3) OTHER 70.4 -27% -32% n/a n/a Total product sales 993.3 +30% +26%

(1) Data provided by IMS Health National Prescription Audit ("IMS NPA"). Exit market share represents the average monthly US market share in the month ended June 30, 2011.

(2) IMS NPA Data not available.

(3) Not sold in the US in Q2 2011.

VYVANSE - ADHD

The growth in VYVANSE product sales resulted from higher prescription demand, due to growth in the US ADHD market and increases to VYVANSE's share of that market, in addition to the effect of price increases taken since Q2 2010. These positive factors were partially offset by higher sales deductions in Q2 2011 compared to Q2 2010, primarily due to a change in the estimate of VYVANSE inventory in the US retail pipeline, which increased sales rebates in the quarter.

ADDERALL XR - ADHD

Product sales grew at a faster rate than US prescription demand due to the effect of significantly lower sales deductions as a percentage of branded gross sales together with the effect of a price increase taken since Q2 2010. Sales deductions were at 59% in Q2 2011 compared to 74% in Q2 2010, which was notably above the average sales deduction levels experienced in other quarters in 2010.

Sales deductions as a percentage of gross product sales decreased in
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SOURCE Shire plc
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