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Shire's New Product Portfolio Delivers Strong Quarterly Performance
Date:10/29/2008

added Jerini's

HAE product, FIRAZYR, to the portfolio.

Sale of non-core assets

- Following the transfer of the relevant marketing consents Shire

recognised previously deferred gains of $4 million arising from the

divestment of non-core products to Laboratorios Almirall S.A

("Almirall") in 2007.

HGT analyst day

Shire is holding an analyst day on November 18, 2008 in Lexington, Massachusetts

Please visit http://www.shire.com for registration and additional information

Dial in details for the live conference call for investors 14:00 GMT/10:00 EDT on October 29, 2008:

UK and International dial in: +44-(0)20-7806-1951

US dial in: +1-718-354-1385

Password/Conf ID: 4688205

Live Webcast:

http://www.shire.com/shire/InvestorRelations/presentations.jsp?tn=2&m1=21

Notes to Editors

SHIRE PLC

Shire's strategic goal is to become the leading specialty biopharmaceutical company that focuses on meeting the needs of the specialist physician. Shire focuses its business on attention deficit hyperactivity disorder (ADHD), human genetic therapies (HGT) and gastrointestinal (GI) diseases as well as opportunities in other therapeutic areas to the extent they arise through acquisitions. Shire's in-licensing, merger and acquisition efforts are focused on products in specialist markets with strong intellectual property protection and global rights. Shire believes that a carefully selected and balanced portfolio of products with strategically aligned and relatively small-scale sales forces will deliver strong results.

For further information on Shire, please visit the Company's website: http://www.shire.com

THE "SAFE HARBOR" STATEMENT UNDER THE PRIVAT
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