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Shire's New Product Portfolio Delivers Strong Quarterly Performance
Date:10/29/2008

folio will continue to deliver strong, high margin growth throughout 2009 and 2010 and provide the platform for future revenue and earnings growth. There are a number of variables that can impact the exact rate of erosion of ADDERALL XR's sales and we have contingency plans in place to cover these different outcomes. While we will continue to invest in the future growth drivers of the business, our discretionary cost base will be tightly managed to deliver expected earnings.

The following items are excluded from net income/(loss) from continuing operations in calculating both 2008 and 2009 Non GAAP diluted earnings:

- Intangible asset amortization and impairment charges;

- Gains and losses on the sale of non-core assets;

- Upfront payments and milestones in respect of in-licensed and acquired

products (including the 2008 payment to Zymenex A/S ("Zymenex") for

METAZYM of $135 million);

- Termination costs (including the 2008 intangible asset impairment

charges, write downs and exit costs of $150m associated with

DYNEPO(R));

- Costs associated with the introduction of the new holding company;

- Costs associated with the acquisition and integration of companies, and

acquired in-process research and development charges (including Jerini

in Q3 2008);

- Other than temporary impairment of investments (including $54 million

impairment in Q3 2008); and

- Taxes associated with these items.

Depreciation, which is included in cost of product sales, R&D costs and selling, general and administrative costs in our GAAP results, has been separately disclosed for the presentation of 2008 Non GAAP earnings (see pages 24 to 28).

Product Highlights

New Product Launches - subject to obtaining the relevant regulatory/governmental approvals, product launches planned over the next two years include:

- MEZAVANT(R) (mesalazine) for u
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SOURCE Shire Plc
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