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Shire's New Product Portfolio Delivers Strong Quarterly Performance
Date:10/29/2008

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operations 12.7 34.7 62.3 (1,663.9)

Loss from discontinued

operations (0.9) - (0.9) -

-------- -------- -------- --------

Numerator for basic and diluted

EPS 11.8 34.7 61.4 (1,663.9)

-------- -------- -------- --------

No. of No. of No. of No. of

Weighted average number of shares shares shares shares

shares: Millions Millions Millions Millions

-------- -------- -------- --------

Basic (1) 540.3 546.4 542.6 538.9

Effect of dilutive shares:

Stock options(2) 1.2 8.2 2.7 -

Warrants(2) - 0.1 - -

-------- -------- -------- --------

Diluted 541.5 554.7 545.3 538.9

-------- -------- -------- --------

(1) Excludes shares purchased by the ESOT and presented by the Company as treasury stock.

(2) Calculated using the treasury stock method.

The share equivalents not included in the above calculation of the diluted
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SOURCE Shire Plc
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