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Shire's New Product Portfolio Delivers Strong Quarterly Performance
Date:10/29/2008

ants - 6.0 - 13.0

Payment of dividend - - (36.4) (29.4)

Payments to acquire shares by ESOT (36.2) (68.6) (140.2) (168.5)

-------- -------- -------- --------

Net cash (used in)/provided by

financing activities(C) (36.5) (61.2) (179.1) 1,647.6

-------- -------- -------- --------

Effect of foreign exchange rate

changes on cash and cash

equivalents (D) (9.5) 2.6 (5.5) 6.0

-------- -------- -------- --------

Net decrease in cash and cash

equivalents(A) +(B) +(C) +(D) (327.9) (35.6) (289.2) (564.0)

Cash and cash equivalents at

beginning of period 801.2 598.5 762.5 1,126.9

-------- -------- -------- --------

Cash and cash equivalents at end

of period 473.3 562.9 473.3 562.9

-------- -------- -------- --------

Unaudited US GAAP results for the three and nine months to September 30, 2008

Selected Notes to the US GAAP Financial Statements
(1) Earnings per share

3 months 3 months 9 months 9 months

to to to to

September September September September

30, 30, 30, 30,

2008 2007 2008 2007

$M $M $M $M

-------- -------- -------- --------

Income/(loss) from continuing'/>"/>

SOURCE Shire Plc
Copyright©2008 PR Newswire.
All rights reserved

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