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Shire's New Product Portfolio Delivers Strong Quarterly Performance
Date:10/29/2008

08.8c)

Loss from discontinued operations (0.2c) - (0.2c) -

-------- -------- -------- --------

Earnings/(loss) per ordinary

share - basic 2.2c 6.4c 11.3c (308.8c)

-------- -------- -------- --------

Earnings per ordinary share -

diluted

Earnings/(loss) from continuing

operations 2.4c 6.3c 11.5c (308.8c)

Loss from discontinued operations (0.2c) - (0.2c) -

-------- -------- -------- --------

Earnings/(loss) per ordinary

share - diluted 2.2c 6.3c 11.3c (308.8c)

-------- -------- -------- --------

Earnings/(loss) per ADS - diluted 6.6c 18.9c 33.9c (926.4c)

-------- -------- -------- --------

Weighted average number of

shares:

Basic 540.3 546.4 542.6 538.9

Diluted 541.5 554.7 545.3 538.9

-------- -------- -------- --------

Unaudited US GAAP results for the three months and nine months to September 30, 2008

Consolidated Statements of Cash Flows

3 months 3 months 9 months 9 months

to to to to

September September September September

30, 30, 30, 30,

2008 2007 2008 2007

$M $M $M $M


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SOURCE Shire Plc
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