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Q3 2008 Unaudited Results

Q3 2008 Q3 2007

Non Non

US GAAP Adjustments GAAP(1) US GAAP Adjustments GAAP(1)

$M $M $M $M $M $M

------ --------- ---------- ------- ---------- ----------

Revenues 778.6 - 778.6 608.7 - 608.7

Operating 122.9 155.7 278.6 22.6 126.0 148.6

income

Net income 11.8 204.2 216.0 34.7 83.7 118.4

Diluted

earnings

per:

Ordinary 2.2c 36.9c 39.1c 6.3c 14.5c 20.8c

share

ADS 6.6c 110.7c 117.3c 18.9c 43.5c 62.4c

Note: Average exchange rates for Q3 2008 and Q3 2007 were $1.89:

GBP1.00 and $2.02: GBP1.00, respectively.

(1) Non GAAP operating income, Non GAAP net income, Non GAAP diluted earnings per ordinary share and Non GAAP diluted earnings per ADS exclude intangible asset amortization charges and other items as described on page 5. For an explanation of why Shire's management believes that these Non GAAP financial measures are useful to investors, see page 5. For a reconciliation of these Non GAAP financial measures to the most directly comparable financial measures prepared in accordance with US GAAP, see pages 24-28.

2008 Updated Financial Outlook

Based on the continued positive sales trends in the third quarter we are able to reiterate the 2008 revenue growth of at least 20% and we also reaffirm the cost guidance given as part of the second quarter 2008 results.

- Guidance, published with our second quarter results, for net
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