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Shire's New Product Portfolio Delivers Strong Quarterly Performance
Date:10/29/2008

p>Cost of product sales (US 84.2 12% 83.4 15%

GAAP)

Depreciation (3.2) (3.1)

-------- ---------

Cost of product sales (Non 81.0 11% 80.3 15%

GAAP)

-------- ---------

The cost of product sales increased to $84.2 million for the three months to September 30, 2008 (12% of product sales), from $83.4 million in the corresponding period in 2007 (15% of product sales). Cost of product sales as a percentage of product sales in the three months to September 30, 2008 compared to the same period in 2007 decreased by 3% points due to favourable changes in product mix.

Research and development ("R&D")

% of

% of product product

2008 sales 2007 sales

$m $m

--------- --------- --------- ---------

R&D (US GAAP) 127.1 18% 181.4 33%

Payment for in-licensed

product - (75.0)

Depreciation (3.4) (2.9)

--------- ---------

R&D (Non GAAP) 123.7 17% 103.5 19%

--------- ---------

R&D expenditure decreased to $127.1 million for the three months to September 30, 2008 (18% of product sales), from $181.4 million in the corresponding period in 2007 (33% of product sales). After excluding depreciation and the up-front payment of $75.0 million to Renovo in respect of JUVISTA made in Q3 2007, R&D ex
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SOURCE Shire Plc
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