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Shire to Introduce a New UK Listed Holding Company
Date:4/14/2008

ted will be substituted in place of Shire, with effect from immediately prior to the Scheme becoming effective, as principal obligor under the US$1,100 million 2.75 per cent. convertible bonds due 2014 originally issued by Shire on 9 May 2007. On and from such substitution, the bonds will be convertible into ordinary shares of Shire Limited.

Conditions to the Implementation of the Proposals

The Scheme will require the approval of Shire ordinary shareholders at a shareholder meeting to be convened at the direction of the High Court (the "Court Meeting"). The approval required at the Court Meeting is a majority in number of Shire ordinary shareholders present and voting (whether in person or by proxy) representing not less than 75% in value of those Shire ordinary shareholders who vote at the meeting.

The Scheme will also require separate approval by not less than 75% of all Shire shareholders who vote (whether in person or by proxy) at an extraordinary general meeting of Shire (the "EGM").

In addition to the approvals mentioned above, the Scheme will be conditional upon the sanction of the Scheme by the High Court. The subsequent reduction of capital of Shire Limited will also require approval at a later hearing of the Royal Court of Jersey.
Expected Timetable of Key Events

3.00 p.m. (New Latest time for receipt by ADS Depositary

York Time), 5th of voting instructions from Shire ADS

May holders for the Court Meeting and EGM

10.30 a.m. and Latest time for receipt of forms of proxy

10.45 a.m. for the Court Meeting and EGM

respectively,

7th May

10.30a.m. and The Court Meeting and EGM

10.45 a.m.

respectively,

9th May

22nd May Last day of dealings in Shire ordinary

shares

22nd May Scheme Record Date

23rd May Scheme Effective Date

23rd M
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SOURCE Shire PLC
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