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Shire to Introduce a New UK Listed Holding Company
Date:4/14/2008

become Shire Limited ADSs on a one-for-one basis, without any action being required on the part of Shire ADS holders, and with each Shire Limited ADS representing three ordinary shares in Shire Limited. The Proposals do not involve any payment for the new ADSs. It is intended that the Shire Limited ADSs will be traded on NASDAQ in place of the Shire ADSs.

Income Access Share Arrangements

Shire Limited intends to put into place, after completion of the Scheme and subject to the passing of a board resolution by Shire Limited, income access share arrangements.

If these arrangements are adopted, then for so long as they remain in operation:

- Shire Limited ordinary shareholders, other than ADS holders, will be able to choose whether they receive their dividends from a company resident for tax purposes in the UK (i.e. Shire) or from a company resident for tax purposes in the Republic of Ireland (i.e. Shire Limited);

- The ADS depositary will be required to elect on behalf of all holders of Shire Limited ADSs to receive their dividends from a company resident for tax purposes in the UK (i.e. Shire);

- Shire Limited ordinary shareholders who hold 25,000 or fewer Shire Limited ordinary shares at the time the Scheme becomes effective, and who do not make a contrary election, will be deemed to have elected to receive their dividends from a company resident for tax purposes in the UK (i.e. Shire); and

- Shire Limited ordinary shareholders who acquire their Shire Limited ordinary shares after the Scheme becomes effective, who hold 25,000 or fewer Shire Limited ordinary shares on the first dividend record date after they become Shire Limited ordinary shareholders and who do not make a contrary election, will be deemed to have elected to receive their dividends from a company resident for tax purposes in the UK (i.e. Shire).

Issuer Substitution under Shire's Convertible Bonds

In connection with the Scheme, Shire Limi
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SOURCE Shire PLC
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