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Shire plc: Long Term Incentive Plan
Date:3/26/2008

BASINGSTOKE, England and PHILADELPHIA, Pennsylvania, March 26 /PRNewswire-FirstCall/ -- Shire plc (LSE: SHP, NASDAQ: SHPGY, TSX: SHQ), the global specialty biopharmaceutical company, announces the release on March 25, 2008, of ordinary shares of 5 pence in the capital of Shire plc ("Shares") in connection with the Shire Long Term Incentive Plan ("LTIP").

In accordance with the rules of the LTIP, the following Shares were released:

Name of PDMR Number of Shares

Released

Mr M Emmens 75,408

Mr A Russell 46,634

Ms T May 30,746

Mr J Rus 23,365

Ms A Graham 18,843

The LTIP awards were subject to performance criteria and, in accordance with the rules of the LTIP, the number of Shares to be released was approved by the Remuneration Committee in 2007. Whilst the performance period is measured over three years, the Shares are only released after the fourth anniversary of the grant. The LTIP awards were satisfied by way of a cash payment, being a sum equal to the cash equivalent of the number of Shares released. The cash equivalent was determined by using the middle market quotation of the Shares on the business day preceding the day on which entitlement arose.

This notification relates to disclosures made in accordance with 3.1.4(R)(1)(a) of the Disclosure Rules and Transparency Rules.
T May

Company Secretary

Notes to editors

Shire plc Shire's strategic goal is to become the leading specialty biopharmaceutical company that focuses on meeting the needs of the Specialist physician. Shire focuses its business on attention deficit and Hyperactivity disorder (ADHD), human genetic therapies (HGT), gastrointestin
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SOURCE Shire plc
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