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Shire plc: IFRS Results for the Year Ending December 31, 2007
Date:3/25/2008

1,796.5 +36

_________ _________ ________

Product sales

Year to December 31,

Product sales US prescription

2007 2006 growth growth

US$M US$M % %

______________ __________ ______________ ________

Specialty

Pharmaceuticals

ADHD

ADDERALL XR 1,030.9 863.6 +19 +3

VYVANSE 76.5 - N/A N/A

DAYTRANA 64.2 25.1 +156 +166

ADDERALL - 23.6 N/A N/A

GI

PENTASA 176.4 137.8 +28 +3

LIALDA/MEZAVANT 50.5 - N/A N/A

RENAL

FOSRENOL 102.2 44.8 +128 +5

DYNEPO 14.2 - N/A N/A

Other

therapeutic

areas

CALCICHEW 54.2 45.5 +19 N/A

CARBATROL 72.3 68.3 +6 -5

XAGRID 66.8 53.3 +25 N/A

REMINYL/REMINYL XL 31.2 21.5 +45 N/A

Other 105.1 111.0 -5

_____________ __________ ______________

1,844.5 1,394.5 +32

_____________ __________ ______________

Human Genetic

Therapies

REPLAGAL 143.9 117.7 +22 N/A

ELAPRASE 181.8 23.6 +670 N/A

_____________ __________ _____________

325.7 141.3 +131

_____________ __________ _____________

Total 2
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SOURCE Shire plc
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