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Shire plc: IFRS Results for the Year Ending December 31, 2007
Date:3/25/2008

(0.1)

Payment of debt issuance costs 8 (32.8) -

Proceeds from drawings under bank facility 8 1,300.0 -

Repayment of drawings under bank facility 8 (1,300.0) -

Proceeds from exercise of New River purchased

call option 141.8 -

Proceeds from issue of ordinary shares, net of

issue costs 877.3 -

Proceeds from exercise of share options 30.4 82.0

Proceeds from exercise of warrants 13.0 -

Payments to acquire shares by ESOT(1) (186.0) (92.0)

Repayment of finance lease obligations (4.3) (5.5)

Dividends paid (41.3) (32.4)

__________ __________

Net cash provided by/(used in) financing

activities 1,618.7 (48.0)

__________ __________

Net (decrease)/increase in cash and cash

equivalents (370.4) 462.5

Cash and cash equivalents at beginning of year 1,126.9 656.5

Effect of foreign currency translation 6.0 7.9

__________ __________

Cash and cash equivalents at end of year 762.5 1,126.9

__________ __________

(1) Employee Share Option Trust

1. General information Shire plc ("the Company") and its subsidiaries (collectively referred to as the "Group" or "Shire") develop and market products for specialty physicians. The Group focuses on four therapeutic areas: ADHD, gast
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SOURCE Shire plc
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6. FDA Approves Additional Dosage Strengths of Shires ADHD Treatment VYVANSE(TM) (lisdexamfetamine dimesylate) Which May Help Physicians Tailor Treatment for Individual Patients
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