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Shire plc: IFRS Results for the Year Ending December 31, 2007
Date:3/25/2008

.5 343.3 +17

Other SG&A costs 329.2 252.9 +30

_______ _______ _______

1,041.4 829.4 +26

Depreciation, amortisation and impairment 339.7 390.5 -13

charges(1)

_______ _______ _______

Total SG&A costs 1,381.1 1,219.9 +13

_______ _______ ______

(1) Excludes (i) depreciation from manufacturing plants of US$5.0 million (2006: US$4.8 million) and amortisation of favourable supply contracts of US$1.2 million (2006: US$nil) which is included in cost of sales and (ii) other intangible assets impairment charges in respect of products under development of US$256.4 million (2006: US$nil) included in R&D.

Excluding depreciation, amortisation and impairment charges, SG&A costs increased by 26% to US$1,041.4 million (2006: US$829.4 million), and represented 48% of product sales (2006: 54%). The increase in SG&A expenses was expected, with additional expenditure required for:

- An increase in the ADHD sales force to promote VYVANSE;

- The cost of the new GI sales force in the US;

- The advertising, promotional and marketing spend to support the launches of VYVANSE, LIALDA and ELAPRASE; and

- A net charge of US$17.0 million in respect of legal settlements, being a charge of US$27.0 million for settlement of the TKT purported securities fraud class action shareholder suit relating to REPLAGAL, partially offset by a US$10.0 million release of existing legal provisions (1% of product sales).

The depreciation charge within SG&A for the year to December 31, 2007 was US$47.3 million (2006: US$36.0 million), which in 2007 included property, plant and equipment write-downs of US$1.8 million (2006: US$0.5 mill
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SOURCE Shire plc
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