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Shire plc: Excellent Performance Across All Areas of the Business and Accelerating New Product Sales Drive Revenue Growth of 36%
Date:2/21/2008

he US Patent No. 5,272,071. Serono's infringement suit against the Company in the Massachusetts's District Court was subsequently dismissed.
Full Year 2007 Unaudited Results

2007 2006

Non Non

US GAAP Adjustments GAAP(1) US GAAP Adjustments GAAP(1)

$M $M $M $M $M $M

_______ _________ __________ _______ __________ _______

Revenues 2,436.3 - 2,436.3 1,796.5 - 1,796.5

Operating

(loss)/income (1,379.1) 2,083.0 703.9 283.2 170.5 453.7

Net (1,451.8) 2,003.1 551.3 278.2 84.2 362.4

(loss)/income

Diluted

earnings per:

Ordinary (268.7c) 366.9c 98.2c 54.6c 16.4c 71.0c

share

ADS (806.1c) 1,100.7c 294.6c 163.8c 49.2c 213.0c

Q4 2007 Unaudited Results

Q4 2007 Q4 2006

Non Non

US GAAP Adjustments GAAP(1) US GAAP Adjustments GAAP(1)

$M $M $M $M $M $M

Revenues 724.5 - 724.5 497.0 - 497.0

Operating

income 232.2 (8.2) 224.0 80.4 34.7 115.1

Net income 212.1 (32.4) 179.7 68.6 27.0 95.6

Diluted

earnings

per:

Ordinary 36.9c (5.6c) 31.3c 13.4c 5.3c 18.7c

share

ADS 110.7c (16.8c) 93.9c 40.2c 15.9c 56.1c

Note: Average exchange rates for 2007 and 2006 were $2.00:GBP1.00 and $1.84:GBP1.00 respectively. Average exchange rates for Q4 <
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SOURCE Shire plc
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