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Shire plc: Excellent Performance Across All Areas of the Business and Accelerating New Product Sales Drive Revenue Growth of 36%
Date:2/21/2008

2,509.9 1,493.2

Accumulated other comprehensive income 55.7 87.8

(Accumulated deficit)/retained earnings (1,140.1) 353.0

_________ ________

Total shareholders' equity 1,227.0 1,942.3

_________ ________

Total liabilities and shareholders' equity 4,330.1 3,326.4

_________ ________

Unaudited US GAAP results for the three months and year to December 31,

2007

Consolidated Statements of Operations

3 months 3 months 12 months 12 months

to to to to

December December December December

31, 2007 31, 2006 31, 2007 31, 2006

$M $M $M $M

________ ________ ________ ________

Revenues:

Product sales 661.3 427.6 2,170.2 1,535.8

Royalties 61.8 61.1 247.2 242.9

Other revenues 1.4 8.3 18.9 17.8

_______ _______ ______ _______

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SOURCE Shire plc
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