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Shire plc: Excellent Performance Across All Areas of the Business and Accelerating New Product Sales Drive Revenue Growth of 36%
Date:2/21/2008

nths to December 31, 2007 decreased by 65% to $66.6 million (2006: $188.8 million). Excluding upfront payments and milestones in respect of in-licensed technology of $75.0 million in 2007 (2006: $nil) (see section 4 - R&D below for details), cash inflow from operating activities for the year to December 31, 2007 decreased by 25% to $141.6 million (2006: $188.8 million). This decrease was primarily as a result of increased receivables generated by higher sales in December 2007 over December 2006.

2. Product sales

For the year to December 31, 2007 product sales increased by 41% to $2,170.2 million (2006: $1,535.8 million) and represented 89% of total revenues (2006: 86%).

Product Highlights

Sales Sales US Rx US Average

$M Growth (2) Growth (1)(2) Annual Market

Product Share(1)

Specialty

Pharmaceuticals

ADDERALL XR 1,030.9 +19% +3% 25.5%

VYVANSE 76.5 n/a n/a 1.8%

DAYTRANA 64.2 +156% +166% 2.1%

PENTASA 176.4 +28% +3% 17.2%

LIALDA 50.5 n/a n/a 3.9%

FOSRENOL 102.2 +128% +5% 8.6%

DYNEPO 14.2 n/a n/a n/a

CARBATROL 72.3 +6% -5% 41.3%

XAGRID 66.8 +25% n/a n/a

Human Genetic Therapies

REPLAGAL 143.9 +22% n/a n/a

ELAPRASE 181.8 +670% n/a n/a

(1) Product specific prescription data is provided by IMS Health ("IMS"), a leading global provider of business intelligence for the pharmaceutical and healthcare indus
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SOURCE Shire plc
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