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Shire plc: Excellent Performance Across All Areas of the Business and Accelerating New Product Sales Drive Revenue Growth of 36%
Date:2/21/2008

itate internal comparisons of the Company's performance to historical results and to competitors' results. These measures are also considered by Shire's Remuneration Committee in assessing the performance and compensation of employees, including its executive directors.

The non GAAP measures are presented in this press release as the Company's management believe that they will provide investors with a means of evaluating, and an understanding of how Shire's management evaluates, the Company's performance and results on a comparable basis that is not otherwise apparent on a US GAAP basis, since many one-time, infrequent or non-cash items that the Company's management believe are not indicative of the core performance of the business may not be excluded when preparing financial measures under US GAAP.

These non GAAP measures should not be considered in isolation from, as substitutes for, or superior to financial measures prepared in accordance with US GAAP.

Dial in details for the live conference call for investors 14:00 GMT/09:00 ET.

UK dial in: 0800-953-0934

US dial in: +1-866-224-2843

International dial in: +44-1452-569-102

Password/Conf ID: 34394878#

Click here for the webcast http://www.shire.com/shire/InvestorRelations/showevent.jsp?tn=2&m1=33&m2= &event=65

(Due to the length of this URL, it may be necessary to copy and paste this hyperlink into your Internet browser's URL address field. Remove the space if one exists.)

The following are trademarks of Shire or companies within the Shire Group which are the subject of trademark registrations in certain territories:

ADDERALL XR(R) (mixed salts of a single-entity amphetamine)

ADDERALL(R) (mixed salts of a single-entity amphetamine)

CALCICHEW(R) range (calcium carbonate with or without vitamin D3)

CARBATROL(R) (
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SOURCE Shire plc
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