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Shire plc: Core Portfolio of Products Delivers 20% Sales Growth
Date:8/5/2009

RAZYR(R) - for the treatment of hereditary angioedema ("HAE")

- In June 2009, Shire initiated a Phase 3 study in patients with acute attacks of HAE, known as the FAST-3 trial, which is designed to support filing of a NDA for FIRAZYR in the US.

2009 OUTLOOK

We are reiterating our previously announced guidance framework for Non GAAP diluted earnings per ADS for 2009, which remains unchanged from that provided in our Q3 2008 earnings release. At that time, and in subsequent earnings releases, we provided details of the effect of changes in foreign exchange rates on the earnings guidance. Specifically, our plans for 2009, supporting Non GAAP diluted earnings per ADS for 2009 in the range of $3.00 to $3.40, were based on average actual foreign exchange rates (EUR1:$1.52, GBP1:$1.95) for the ten months to October 2008. During the first half of 2009 we have already achieved Non GAAP diluted earnings per ADS of $1.88.

We identified that each 10c movement in the EUR:$ and GBP:$ exchange rates impacts Shire's Non GAAP diluted earnings per ADS by $0.10 and $0.01 respectively. Based on the following exchange rate scenarios, which are not forecasts, the impact on our base guidance would be:


                                      Euro fx     GBP fx    Non GAAP diluted
                                       rate        rate     earnings per ADS
                                                                range (1)

    Base guidance                      $1.52      $1.95      $3.00 to $3.40
    At average March 2009 exchange     $1.30      $1.42      $2.73 to $3.13
    rates
    At average H1 2009 & July 2009     $1.37      $1.56      $2.80 to $3.20
    exchange rates

(1) Our guidance framework for Non GAAP diluted earnings per ADS is not prepared in accordance with US GAAP. Non GAAP diluted earnings per ADS excludes the effect of certain cash and non-cash items,
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SOURCE Shire Plc
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