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Shire plc: Core Portfolio of Products Delivers 20% Sales Growth
Date:8/5/2009

Q2 2009 US GAAP Adjustments Non GAAP(1) $M $M $M Revenues 630 - 630 Operating income/(loss) 35 81 116 Net income/(loss) 44 65 109 Diluted earnings/(loss) per ADS 24c 36c 60c continued... Q2 2008 US GAAP Adjustments Non GAAP(1) $M $M $M Revenues 776 - 776 Operating income/(loss) (67) 314 247 Net income/(loss) (79) 267 188 Diluted earnings/(loss) per ADS (44c) 139c 95c

Note: Average exchange rates for Q2 2009 were $1.55:GBP1.00 and $1.36:EUR1.00, (Q2 2008: $1.97:GBP1.00 and $1.57:EUR1.00).

(1) The Non GAAP financial measures included above are explained on pages 26 and 27, together with an explanation of why Shire's management believes that these measures are useful to investors. For a reconciliation of these Non GAAP financial measures to the most directly comparable financial measures prepared in accordance with US GAAP, see pages 22 and 23.

    FINANCIAL SUMMARY

    Second Quarter 2009 (see page 6 for full Financial Results)

    - Product sales excluding ADDERALL XR(R) were up 20% (up 27% at CER) to
      $491 million, following continued growth from VYVANSE(R) (up 75% to
      $114 million) and LIALDA(R)/MEZAVANT(R) (up 71% to $55 million).

    - Total product sales, including ADDERALL XR, were down 21% to $558
      million, as ADDERALL XR product sales declined by 77%, or $229 million
      to $67 million, as a result of the la
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SOURCE Shire Plc
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