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Shire plc: Core Portfolio of Products Delivers 20% Sales Growth
Date:8/5/2009

he ESOT and presented by the Company as treasury stock.

(3) Calculated using the treasury stock method.

(4) Calculated using the "if-converted" method.

The share equivalents not included in the calculation of the diluted weighted average number of shares are shown below:

                           3 months to  3 months to  6 months to  6 months to
                              June 30,     June 30,     June 30,     June 30,
                                  2009         2008         2009         2008
                           Millions(1)               Millions(1)
                                   (2)  Millions(3)          (2)  Millions(1)
    Stock options in the
    money                            -          1.3            -            -
    Stock options out of
    the money                     31.3         17.9         18.9         17.4
    Convertible bonds 2.75%
    due 2014                      32.7         32.7         32.7            -

(1) For the three month period ended June 30, 2009 and the six month periods ended June 30, 2009 and 2008, certain stock options have been excluded from the calculation of diluted EPS because their exercise prices exceeded Shire plc's average share price during the calculation period.

(2) For the three and six month periods ended June 30, 2009 the ordinary shares underlying the convertible bonds have not been included in the calculation of the diluted weighted average number of shares, because the effect of their inclusion would be anti-dilutive.

(3) For the three month period ended June 30, 2008 no share options or ordinary shares underlying the convertible bonds have been included in the calculation of the diluted weighted average number of shares because the Company made a net loss during the calculation period and the inclusion of these items would be anti-dilutive.

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SOURCE Shire Plc
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