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Shire plc: Core Portfolio of Products Delivers 20% Sales Growth
Date:8/5/2009

June June June 30, 30, June 30, 30, 2009 2008 2009 2008 Earnings/(loss) per ordinary share - basic Earnings/(loss) from continuing operations 10.0c (14.6c) 50.0c 9.1c Loss from discontinued operations (1.8c) - (2.3c) - Earnings/(loss) per ordinary share - basic 8.2c (14.6c) 47.7c 9.1c Earnings/(loss) per ADS - basic 24.6c (43.8c) 143.1c 27.3c Earnings/(loss) per ordinary share - diluted Earnings/(loss) from continuing (14.6c) 8.2c operations 9.9c 49.6c Loss from discontinued operations (1.8c) - (2.3c) - Earnings/(loss) per ordinary share - diluted 8.1c (14.6c) 47.3c 8.2c Earnings/(loss) per ADS - diluted 24.3c (43.8c) 141.9c 24.6c Weighted average number of shares (millions): Basic 539.9 542.5 539.7 543.7 Diluted 543.4 542.5 545.0 579.6

Unaudited US GAAP results for the three months and six months to June 30, 2009 Consolidated Statements of Cash Flows

                                                        3                  6
                                         3 months  months  6 months   months
                                               to      to        to       to
                                                      June               June
                                         June 30,     30,  June 30,      30,
                   
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SOURCE Shire Plc
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