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Shire plc: Core Portfolio of Products Delivers 20% Sales Growth
Date:8/5/2009

arily results from changes to the product mix following the launch by Teva of an authorized generic version of ADDERALL XR in April 2009; higher sales deductions on Shire's sales of branded ADDERALL XR, together with lower margin sales of the authorized generic version of ADDERALL XR to Teva have both depressed gross margin for that product.

    Research and development ("R&D")

                                            % of              % of
                                         product           product
                               2009        sales     2008    sales
                                 $M                    $M
    R&D (US GAAP)             158.7          28%    136.4      19%
    INTUNIV license payment   (36.9)                    -
    DYNEPO R&D commitments        -                  (6.5)
    Depreciation               (3.8)                 (3.1)
    R&D (Non GAAP)            118.0          21%    126.8      18%

Non GAAP R&D decreased 7% to $118.0 million (2008: $126.8 million). The continued investment in core R&D programs has been offset by the benefit of foreign exchange rates in Q2 2009 over the same period in 2008 and the cessation of certain non-core programs since Q2 2008. As a percentage of product sales, Non GAAP R&D increased to 21% (2008: 18%) due to the lower product sales in Q2 2009.

    Selling, general and administrative ("SG&A")

                                            % of              % of
                                         product           product
                                   2009    sales     2008    sales
                                     $M                $M
    SG&A (US GAAP)                334.7      60%    437.7      62%
    Intangible asset
    amortization                  (34.3)            (31.0)
    Impairment of intangible
    assets                            -             (90.4)
    
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SOURCE Shire Plc
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