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Shire plc: Core Portfolio of Products Delivers 20% Sales Growth
Date:8/5/2009

illion (2008: $nil). Receipt of this royalty began with Teva's sales of authorized generic ADDERALL XR in April 2009.

OTHER

Other royalties are primarily in respect of REMINYL(R) and REMINYL XL(TM) (known as RAZADYNE(R) and RAZADYNE(R) ER in the US), for the symptomatic treatment of mild to moderately severe dementia of the Alzheimer's type.

The range of REMINYL products is marketed worldwide (excluding the UK and the Republic of Ireland where Shire has exclusive marketing rights) by Janssen Pharmaceutical N.V., an affiliate of Johnson & Johnson ("J&J"). Sales of the REMINYL/RAZADYNE range continue to grow in most countries, however the entry of generic versions of RAZADYNE and RAZADYNE ER into the US market in Q3 2008 has significantly decreased sales in that region.

    4. Financial details
    Cost of product sales

                                                % of              % of
                                             product           product
                                   2009        sales     2008    sales
                                     $M                    $M
    Cost of product sales (US
    GAAP)                          96.4          17%    142.9      20%
    Accelerated depreciation on
    transfer of manufacturing
    from Owings Mills              (3.0)                    -
    Fair value adjustment for
    acquired inventories           (1.4)                    -
    Write down of inventory and
    exit costs for DYNEPO             -                 (53.4)
    Depreciation                   (4.9)                 (3.0)
    Cost of product sales (Non
    GAAP)                          87.1          16%     86.5      12%


After the exclusion of those charges outlined above, Non GAAP cost of product sales as a percentage of product sales increased by 4 percentage points (from 12% to 16%) compared to 2008. This increase prim
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SOURCE Shire Plc
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